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Bioactive platycodins from Platycodonis Radix: Phytochemistry, pharmacological activities, toxicology and pharmacokinetics Journal article
Food Chemistry, 2020,Volume: 327
Authors:  Zhang,Le Le;  Huang,Mu Yang;  Yang,Yong;  Huang,Ming Qing;  Shi,Jia Jie;  Zou,Liang;  Lu,Jin Jian
Favorite |  | TC[WOS]:2 TC[Scopus]:1 | Submit date:2021/03/02
Pharmacokinetics  Pharmacological activities  Phytochemistry  Platycodins  Platycodonis Radix  Toxicology  
Bioactive platycodins from Platycodonis Radix: Phytochemistry, pharmacological activities, toxicology and pharmacokinetics Journal article
Food Chemistry, 2020,Volume: 327
Authors:  Zhang,Le Le;  Huang,Mu Yang;  Yang,Yong;  Huang,Ming Qing;  Shi,Jia Jie;  Zou,Liang;  Lu,Jin Jian
Favorite |  | TC[WOS]:2 TC[Scopus]:1 | Submit date:2021/03/02
Pharmacokinetics  Pharmacological activities  Phytochemistry  Platycodins  Platycodonis Radix  Toxicology  
Nagilactone E increases PD-L1 expression through activation of c-Jun in lung cancer cells Journal article
Chinese Journal of Natural Medicines, 2020,Volume: 18,Issue: 7,Page: 517-525
Authors:  CHEN,Yu Chi;  HUANG,Mu Yang;  ZHANG,Le Le;  FENG,Zhe Ling;  JIANG,Xiao Ming;  YUAN,Luo Wei;  HUANG,Run Yue;  LIU,Bo;  YU,Hua;  WANG,Yi Tao;  CHEN,Xiu Ping;  LIN,Li Gen;  LU,Jin Jian
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c-Jun  JNK  Lung cancer  Nagilactone E  Programmed death ligand 1  
Identification of nagilactone E as a protein synthesis inhibitor with anticancer activity Journal article
Acta Pharmacologica Sinica, 2020,Volume: 41,Issue: 5,Page: 698-705
Authors:  Zhang,Le le;  Guo,Jing;  Jiang,Xiao ming;  Chen,Xiu ping;  Wang,Yi tao;  Li,Ao;  Lin,Li gen;  Li,Hua;  Lu,Jin jian
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Click-iT  CMap  diterpenoids  human lung cancer A549 cell line xenograft  molecular docking  nagilactone E  protein synthesis inhibitor  RIOK2  RNA-seq  
Activation of notch 3/c-MYC/CHOP axis regulates apoptosis and promotes sensitivity of lung cancer cells to mTOR inhibitor everolimus Journal article
Biochemical Pharmacology, 2020,Volume: 175
Authors:  Li,Ting;  Xu,Xiao Huang;  Guo,Xia;  Yuan,Tao;  Tang,Zheng Hai;  Jiang,Xiao Ming;  Xu,Yu Lian;  Zhang,Le Le;  Chen,Xiuping;  Zhu,Hong;  Shi,Jia Jie;  Lu,Jin Jian
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Apoptosis  c-MYC  CHOP  Lung cancer  Notch 3  
Ruthenium-Catalyzed Direct Asymmetric Reductive Amination of Diaryl and Sterically Hindered Ketones with Ammonium Salts and H2 Journal article
Angewandte Chemie - International Edition, 2020,Volume: 59,Issue: 13,Page: 5321-5325
Authors:  Hu,Le' an;  Zhang,Yao;  Zhang,Qing Wen;  Yin,Qin;  Zhang,Xumu
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amines  diaryl ketones  homogeneous catalysis  reductive amination  ruthenium  
Nagilactone D ameliorates experimental pulmonary fibrosis in vitro and in vivo via modulating TGF-β/Smad signaling pathway Journal article
Toxicology and Applied Pharmacology, 2020,Volume: 389
Authors:  Li,Ao;  Xiao,Xiao;  Feng,Zhe Ling;  Chen,Xiuping;  Liu,Li Juan;  Lin,Li Gen;  Lu,Jin Jian;  Zhang,Le Le
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Bleomycin  Fibrotic process  Nagilactone D  Pulmonary fibrosis  TGF-β1  
Phanginin R induces cytoprotective autophagy via JNK/C-JUN signaling pathway in non-small cell lung cancer A549 cells Journal article
Anti-Cancer Agents in Medicinal Chemistry, 2020,Volume: 20,Issue: 8,Page: 982-988
Authors:  Zhang,Le Le;  Bao,Han;  Xu,Yu Lian;  Jiang,Xiao Ming;  Li,Wei;  Zou,Liang;  Lin,Li Gen;  Lu,Jin Jian
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Anti-cancer  Autophagy  C-Jun  JNK  Non-small cell lung cancer  Phanginin R  
TGFβ2-mediated epithelial–mesenchymal transition and NF-κB pathway activation contribute to osimertinib resistance Journal article
Acta Pharmacologica Sinica, 2020
Authors:  Jiang,Xiao ming;  Xu,Yu lian;  Yuan,Luo wei;  Zhang,Le le;  Huang,Mu yang;  Ye,Zi han;  Su,Min xia;  Chen,Xiu ping;  Zhu,Hong;  Ye,Richard D.;  Lu,Jin jian
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EGFR mutant non-small cell lung cancer  epithelial-mesenchymal transition  NF-κB  osimertinib resistance  TGFβ2  
PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation Journal article
Autophagy, 2020
Authors:  Wu,Ming Yue;  Liu,Le;  Wang,Er Jin;  Xiao,Hai Tao;  Cai,Cui Zan;  Wang,Jing;  Su,Huanxing;  Wang,Yitao;  Tan,Jieqiong;  Zhang,Zhuohua;  Wang,Juan;  Yao,Maojing;  Ouyang,De Fang;  Yue,Zhenyu;  Li,Min;  Chen,Ye;  Bian,Zhao Xiang;  Lu,Jia Hong
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Apoptotic cell clearance  inflammatory bowel disease  macrophage  MON1-CCZ1  NRBF2  RAB7