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Acetyltanshinone IIA reduces the synthesis of cell cycle-related proteins by degrading p70S6K and subsequently inhibits drug-resistant lung cancer cell growth Journal article
Pharmacological Research, 2022,Volume: 179
Authors:  Huang, Bin;  Hao, Meng;  Li, Chuwen;  Luo, Kathy Qian
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/05/13
Acetyltanshinone Iia  Afatinib (Pubchem Cid: 10184653)  Aurora Kinase a  Drug-resistant Lung Cancer  Egfr  Erlotinib (Pubchem Cid: 176870)  Ly294002 (Pubchem Cid: 3973)  Mln8237 (Pubchem Cid: 24771867)  Osimertinib (Pubchem Cid: 71496458)  P70s6k  Pf-4708671 (Pubchem Cid: 51371303)  Rapamycin (Pubchem Cid: 5284616)  Tanshinone Iia (Pubchem Cid: 164676)  
Zebrafish: A Promising Model for Evaluating the Toxicity of Carbon Dot-Based Nanomaterials Journal article
ACS Applied Materials and Interfaces, 2020,Volume: 12,Issue: 43,Page: 49012-49020
Authors:  Liu,Wei;  Huang,Gang;  Su,Xiaoying;  Li,Siyi;  Wang,Qun;  Zhao,Yuying;  Liu,Yao;  Luo,Jingshan;  Li,Ye;  Li,Chuwen;  Yuan,Dongsheng;  Hong,Honghai;  Chen,Xiaojia;  Chen,Tongkai
Favorite |  | TC[WOS]:13 TC[Scopus]:12 | Submit date：2021/03/02
Carbon Nanomaterials  Developmental Neurotoxicity  Dopamine  Nanotoxicology  Zebrafish (Danio Rerio)  
Oxyphylla a promotes degradation of α-synuclein for neuroprotection via activation of immunoproteasome Journal article
Aging and Disease, 2020,Volume: 11,Issue: 3,Page: 559-574
Authors:  Zhou,Hefeng;  Li,Shengnan;  Li,Chuwen;  Yang,Xuanjun;  Li,Haitao;  Zhong,Hanbing;  Lu,Jia Hong;  Lee,Simon Ming Yuen
Favorite |  | TC[WOS]:7 TC[Scopus]:7 | Submit date：2021/03/01
Parkinson's Disease  Α-synuclein  Degradation  Proteasome  Neuroprotection  
Tetramethylpyrazine Analogue T-006 Exerts Neuroprotective Effects against 6-Hydroxydopamine-Induced Parkinson's Disease In Vitro and In Vivo Journal article
Oxidative Medicine and Cellular Longevity, 2019,Volume: 2019
Authors:  Zhou,Hefeng;  Shao,Min;  Yang,Xuanjun;  Li,Chuwen;  Cui,Guozhen;  Gao,Cheng;  Di,Lijun;  Zhong,Hanbing;  Wang,Yuqiang;  Zhang,Zaijun;  Lee,Simon Ming Yuen
Favorite |  | TC[WOS]:10 TC[Scopus]:9 | Submit date：2021/03/01
Tetramethylpyrazine Analogue T-006 Promotes the Clearance of Alpha-synuclein by Enhancing Proteasome Activity in Parkinson’s Disease Models Journal article
Neurotherapeutics, 2019,Volume: 16,Issue: 4,Page: 1225-1236
Authors:  Zhou,Hefeng;  Shao,Min;  Guo,Baojian;  Li,Chuwen;  Lu,Yucong;  Yang,Xuanjun;  ShengnanLi,;  Li,Haitao;  Zhu,Qi;  Zhong,Hanbing;  Wang,Yuqiang;  Zhang,Zaijun;  Lu,Jiahong;  Lee,Simon Ming Yuen
Favorite |  | TC[WOS]:15 TC[Scopus]:15 | Submit date：2021/03/01
Degradation  Lmp7  Parkinson’s Disease  Proteasome Activity  Α-synuclein  
Pinostrobin Exerts Neuroprotective Actions in Neurotoxin-Induced Parkinson's Disease Models through Nrf2 Induction Journal article
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2018,Volume: 66,Issue: 31,Page: 8307-8318
Authors:  Li, Chuwen;  Tang, Benqin;  Feng, Yu;  Tang, Fan;  Hoi, Maggie Pui-Man;  Su, Ziren;  Lee, Simon Ming-Yuen
Favorite |  | TC[WOS]:35 TC[Scopus]:37 | Submit date：2018/10/31
Pinostrobin  Parkinson's Disease  Neurotoxin  Nrf2  
Schisantherin A Attenuates Neuroinflammation in Activated Microglia: Role of Nrf2 Activation Through ERK Phosphorylation Journal article
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018,Volume: 47,Issue: 5,Page: 1769-1784
Authors:  Li, Chuwen;  Chen, Tongkai;  Zhou, Hefeng;  Zhang, Chao;  Feng, Yu;  Tang, Fan;  Hoi, Maggie Pui-Man;  He, Chengwei;  Zheng, Ying;  Lee, Simon Ming-Yuen
Favorite |  | TC[WOS]:25 TC[Scopus]:27 | Submit date：2018/10/30
Schisantherin a  Neuroinflammation  Microglia  Nrf2  Nf-kappa b  
BHDPC Is a Novel Neuroprotectant That Provides Anti-neuroinflammatory and Neuroprotective Effects by Inactivating NF-kappa B and Activating PKA/CREB Journal article
FRONTIERS IN PHARMACOLOGY, 2018,Volume: 9
Authors:  Li, Chuwen;  Chen, Tongkai;  Zhou, Hefeng;  Feng, Yu;  Hoi, Maggie P. M.;  Ma, Dan;  Zhao, Chao;  Zheng, Ying;  Lee, Simon M. Y.
Favorite |  | TC[WOS]:11 TC[Scopus]:13 | Submit date：2018/10/30
Bhdpc  Neuroinflammation  Microglia  Nf-kappa b  Creb  Pka  
Inhibitory Effects of Betulinic Acid on LPS-Induced Neuroinflammation Involve M2 Microglial Polarization via CaMKK beta-Dependent AMPK Activation Journal article
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2018,Volume: 11
Authors:  Li, Chuwen;  Zhang, Chao;  Zhou, Hefeng;  Feng, Yu;  Tang, Fan;  Hoi, Maggie P. M.;  He, Chengwei;  Ma, Dan;  Zhao, Chao;  Lee, Simon M. Y.
Favorite |  | TC[WOS]:36 TC[Scopus]:37 | Submit date：2018/10/30
Amp-activated Protein Kinase  Betulinic Acid  Calmodulin-dependent Protein Kinase Beta  Microglia Polarization  Neuroinflammation  
A novel compound DT-010 protects against doxorubicin-induced cardiotoxicity in zebrafish and H9c2 cells by inhibiting reactive oxygen species-mediated apoptotic and autophagic pathways Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 820,Page: 86-96
Authors:  Tang, Fan;  Zhou, Xinhua;  Wang, Liang;  Shan, Luchen;  Li, Chuwen;  Zhou, Hefeng;  Lee, Simon Ming-Yuen;  Hoi, Maggie Pui-Man
Favorite |  | TC[WOS]:29 TC[Scopus]:28 | Submit date：2018/10/30
Cardioprotection  Anti-oxidative Stress  Anti-apoptosis  Autophagy Regulation  Zebrafish Cardiotoxicity  H9c2 Cardiomyocytes