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Canthin-6-one (CO) from Picrasma quassioides (D.Don) Benn. ameliorates lipopolysaccharide (LPS)-induced astrocyte activation and associated brain endothelial disruption Journal article
Phytomedicine, 2022,Volume: 101
Authors:  Yue, Qian;  Xu, Yunshao;  Lin, Ligen;  Hoi, Maggie Pui Man
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/05/31
Astrocyte  Blood-brain Barrier (Bbb)  Brain Endothelial Cell  Canthin-6-one (Co)  Endothelial Integrity  Neuroinflammation  
Mitochondrial Sirtuin-3 (SIRT3) Prevents Doxorubicin-Induced Dilated Cardiomyopathy by Modulating Protein Acetylation and Oxidative Stress Journal article
Circulation. Heart failure, 2022,Volume: 15,Issue: 5
Authors:  Tomczyk, Mateusz M.;  Cheung, Kyle G.;  Xiang, Bo;  Tamanna, Nahid;  Fonseca Teixeira, Ana L.;  Agarwal, Prasoon;  Kereliuk, Stephanie M.;  Spicer, Victor;  Lin, Ligen;  Treberg, Jason;  Tong, Qiang;  Dolinsky, Vernon W.
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/06/10
Acetylation  Dilated Cardiomyopathy  Doxorubicin  Mitochondria  Superoxide  
Mechanistic Investigation of GHS-R Mediated Glucose-Stimulated Insulin Secretion in Pancreatic Islets Journal article
Biomolecules, 2022,Volume: 12,Issue: 3
Authors:  Pradhan, Geetali;  Lee, Jong Han;  Wu, Chia Shan;  Wang, Hongying;  Lin, Ligen;  Donti, Taraka;  Graham, Brett H.;  Rajan, Arun S.;  Balasubramanyam, Ashok;  Samson, Susan L.;  Guo, Shaodong;  Sun, Yuxiang
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/03/28
Glucose Transporter 2 (Glut2)  Glucose-stimulated Insulin Secretion (Gsis)  Growth Hormone Secretagogue Receptor (Ghs-r)  Insulin  Islets  Pancreatic And Duodenal Homeobox 1 (Pdx1)  
Anti-proliferative cassane-type diterpenoids from the seeds of Caesalpinia minax Journal article
Natural Product Research, 2022,Volume: 36,Issue: 4,Page: 932-941
Authors:  Xu,Yunshao;  Shi,Wei;  Feng,Lu;  Cao,Jun;  Feng,Zheling;  Zhang,Qingwen;  Lu,Jinjian;  Ye,Yang;  Lin,Ligen
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date:2021/03/01
Caesalpinia Minax  Cassane Diterpenoids  Cytotoxic Activity  Fabaceae  
Proteome-wide Identification of Off-Targets of a Potent EGFRL858R/T790MMutant Inhibitor Journal article
ACS Medicinal Chemistry Letters, 2022,Volume: 13,Issue: 2,Page: 292-297
Authors:  Lyu, Peng;  Jiang, Kaili;  Zhou, Yuee;  Hu, Jun;  Chang, Yu;  Zhang, Zhang;  Huang, Minhao;  Zhang, Zhi Min;  Ding, Ke;  Hao, Piliang;  Lin, Ligen;  Li, Zhengqiu
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/03/04
Bioimaging  Chemoproteomics  Egfr T790m  Nt5dc1  Target Identification  
The role of irisin in metabolic flexibility: Beyond adipose tissue browning Journal article
Drug Discovery Today, 2022
Authors:  Shen, Shengnan;  Liao, Qiwen;  Chen, Xiuping;  Peng, Cheng;  Lin, Ligen
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/05/17
FNDC5  Insulin sensitivity  Irisin  Metabolic flexibility  Obesity  Skeletal muscle  
Macrocephatriolides A and B: Two Guaianolide Trimers from Ainsliaea macrocephala as PTP1B Inhibitors and Insulin Sensitizers Journal article
Journal of Organic Chemistry, 2021,Volume: 86,Issue: 24,Page: 17782-17789
Authors:  Ren, Yong Mei;  Zhang, Rui;  Feng, Zheling;  Ke, Chang Qiang;  Yao, Sheng;  Tang, Chunping;  Lin, Ligen;  Ye, Yang
Favorite |  | TC[WOS]:1 TC[Scopus]:1 | Submit date:2022/01/14
Caesalpinaxin, a cassane-type diterpenoid with a 21-carbon core skeleton from the seeds of Caesalpinia minax possessing pro-angiogenetic property Journal article
Bioorganic Chemistry, 2021,Volume: 117
Authors:  Lou, Ruohan;  Xu, Fan;  Xu, Yunshao;  Chen, Jiali;  Feng, Zheling;  Gan, Lishe;  Lin, Ligen
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/12/08
Angiogenesis  Caesalpinaxin  Cassalpinia Minax  Ecd  Fabaceae  
Honokiol attenuates lipotoxicity in hepatocytes via activating SIRT3-AMPK mediated lipophagy Journal article
Chinese Medicine (United Kingdom), 2021,Volume: 16,Issue: 1
Authors:  Liu, Jingxin;  Zhang, Tian;  Zhu, Jianzhong;  Ruan, Shuangchen;  Li, Rongsong;  Guo, Bing;  Lin, Ligen
Favorite |  | TC[WOS]:1 TC[Scopus]:2 | Submit date:2021/12/08
Hepatocytes  Honokiol  Lipid Accumulation  Lipolysis  Lipophagy  Sirt3  
Guaianolides from Artemisia codonocephala suppress interleukine-1β secretion in macrophages Journal article
Phytochemistry, 2021,Volume: 192
Authors:  Wang, Qiaoqiao;  Zhang, Tian;  Ke, Chang Qiang;  Tang, Chunping;  Yao, Sheng;  Lin, Ligen;  Ye, Yang
Favorite |  | TC[WOS]:1 TC[Scopus]:1 | Submit date:2021/12/08
Anti-inflammation  Artemisia Codonocephala  Asteraceae  Guaianolides  Il-1β  Nlrp3