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TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2 Journal article
Acta Pharmacologica Sinica, 2022,Volume: 43,Issue: 5,Page: 1251-1263
Authors:  Yang, Chuan bin;  Liu, Jia;  Tong, Benjamin Chun Kit;  Wang, Zi ying;  Zhu, Zhou;  Su, Cheng fu;  Sreenivasmurthy, Sravan Gopalkrishnashetty;  Wu, Jia xi;  Iyaswamy, Ashok;  Krishnamoorthi, Senthilkumar;  Huang, Shi ying;  Cheung, King ho;  Song, Ju xian;  Tan, Jie qiong;  Lu, Jia hong;  Li, Min
Favorite |  | TC[WOS]:1 TC[Scopus]:2 | Submit date：2022/05/13
15-deoxy-∆-12,14-prostaglandin J2 (15d-PGJ2)  apoptosis  ATF4  autophagy and lysosome biogenesis  ER stress  transcriptional factor EB (TFEB)  
Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles Journal article
Acta Pharmaceutica Sinica B, 2022,Volume: 12,Issue: 4,Page: 1688-1706
Authors:  Deng, Zhiqiang;  Dong, Yu;  Zhou, Xiaoting;  Lu, Jia Hong;  Yue, Zhenyu
Favorite |  | TC[WOS]:0 TC[Scopus]:1 | Submit date：2022/05/13
Alzheimer's disease  Autophagy  Autophagy modulators  Genetic modulation  LC3-associated phagocytosis  Microglial autophagy  Neuroinflammation  Neuronal autophagy  
c-MYC-mediated TRIB3/P62+ aggresomes accumulation triggers paraptosis upon the combination of everolimus and ginsenoside Rh2 Journal article
Acta Pharmaceutica Sinica B, 2022,Volume: 12,Issue: 3,Page: 1240-1253
Authors:  Su, Min Xia;  Xu, Yu Lian;  Jiang, Xiao Ming;  Huang, Mu Yang;  Zhang, Le Le;  Yuan, Luo Wei;  Xu, Xiao Huang;  Zhu, Qi;  Gao, Jian Li;  Lu, Jia Hong;  Chen, Xiuping;  Huang, Ming Qing;  Wang, Yitao;  Lu, Jin Jian
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/04/06
Aggresomes  C-myc  Everolimus  Ginsenoside Rh2  Lung Cancer  P62  Paraptosis  Trib3  
Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease Journal article
Autophagy, 2022,Volume: 18,Issue: 3,Page: 624-642
Authors:  Tong, Benjamin Chun Kit;  Wu, Aston Jiaxi;  Huang, Alexis Shiying;  Dong, Rui;  Malampati, Sandeep;  Iyaswamy, Ashok;  Krishnamoorthi, Senthilkumar;  Sreenivasmurthy, Sravan Gopalkrishnashetty;  Zhu, Zhou;  Su, Chengfu;  Liu, Jia;  Song, Juxian;  Lu, Jia Hong;  Tan, Jieqiong;  Pan, Weidong;  Li, Min;  Cheung, King Ho
Favorite |  | TC[WOS]:4 TC[Scopus]:7 | Submit date：2022/05/17
Alzheimer Disease  Autophagy-lysosomal Pathway  Calcium Ion  Presenilin-1  Two Pore Segment Channel 2  
Emerging roles of NRBF2/PI3KC3 axis in maintaining homeostasis of brain and guts Journal article
Neural Regeneration Research, 2022,Volume: 17,Issue: 2,Page: 323-324
Authors:  Wu, Ming Yue;  Cai, Cui Zan;  Yang, Chuanbin;  Yue, Zhenyu;  Chen, Ye;  Bian, Zhao Xiang;  Li, Min;  Lu, Jia Hong
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/03/04
Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition Journal article
Phytomedicine, 2022,Volume: 96
Authors:  Sreenivasmurthy, Sravan Gopalkrishnashetty;  Iyaswamy, Ashok;  Krishnamoorthi, Senthilkumar;  Senapati, Sanjib;  Malampati, Sandeep;  Zhu, Zhou;  Su, Cheng Fu;  Liu, Jia;  Guan, Xin Jie;  Tong, Benjamin Chun Kit;  Cheung, King Ho;  Tan, Jie Qiong;  Lu, Jia Hong;  Durairajan, Siva Sundara Kumar;  Song, Ju Xian;  Li, Min
Favorite |  | TC[WOS]:2 TC[Scopus]:3 | Submit date：2022/03/04
3xtg-ad Mice  Alzheimer's Disease  Hdac6  P301s-tau Mice  Phospho-tau  Protopine  
Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow Journal article
Nature Biomedical Engineering, 2022,Volume: 6,Issue: 1,Page: 76-93
Authors:  Xie, Chenglong;  Zhuang, Xu Xu;  Niu, Zhangming;  Ai, Ruixue;  Lautrup, Sofie;  Zheng, Shuangjia;  Jiang, Yinghui;  Han, Ruiyu;  Gupta, Tanima Sen;  Cao, Shuqin;  Lagartos-Donate, Maria Jose;  Cai, Cui Zan;  Xie, Li Ming;  Caponio, Domenica;  Wang, Wen Wen;  Schmauck-Medina, Tomas;  Zhang, Jianying;  Wang, He ling;  Lou, Guofeng;  Xiao, Xianglu;  Zheng, Wenhua;  Palikaras, Konstantinos;  Yang, Guang;  Caldwell, Kim A.;  Caldwell, Guy A.;  Shen, Han Ming;  Nilsen, Hilde;  Lu, Jia Hong;  Fang, Evandro F.
Favorite |  | TC[WOS]:2 TC[Scopus]:6 | Submit date：2022/02/21
A synergized machine learning plus cross-species wet-lab validation approach identifies neuronal mitophagy inducers inhibiting Alzheimer disease Other
2022-01-01
Authors:  Ai, Ruixue;  Zhuang, Xu Xu;  Anisimov, Alexander;  Lu, Jia Hong;  Fang, Evandro F.
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/05/17
Aging  Alzheimer’s disease  autophagy  machine learning  mitophagy  
Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy Journal article
Acta Pharmacologica Sinica, 2022
Authors:  Zhu, Zhou;  Liu, Liang feng;  Su, Cheng fu;  Liu, Jia;  Tong, Benjamin Chun Kit;  Iyaswamy, Ashok;  Krishnamoorthi, Senthilkumar;  Sreenivasmurthy, Sravan Gopalkrishnashetty;  Guan, Xin jie;  Kan, Yu xuan;  Xie, Wen jian;  Zhao, Chen liang;  Cheung, King ho;  Lu, Jia hong;  Tan, Jie qiong;  Zhang, Hong jie;  Song, Ju xian;  Li, Min
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/05/17
autophagy  corynoxine B  dopaminergic neuron  MPP+  oxindole alkaloid  Parkinson’s disease  PI3P  PIK3C3 complex  
Adenine base-editing-mediated exon skipping induces gene knockout in cultured pig cells Journal article
Biotechnology Letters, 2022,Volume: 44,Issue: 1,Page: 59-76
Authors:  Zhu, Xiang xing;  Pan, Jia sheng;  Lin, Tao;  Yang, Ye cheng;  Huang, Qiu yan;  Yang, Shuai peng;  Qu, Zi xiao;  Lin, Zi sheng;  Wen, Jian cong;  Yan, Ai fen;  Feng, Juan;  Liu, Lian;  Zhang, Xiao li;  Lu, Jia hong;  Tang, Dong sheng
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/03/28
Adenine Base Editor (Abe)  Base-editing  Exon Skipping  Gene-knockout  Growth Hormone Receptor (Ghr)  Pig Cells