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A Danshensu-Tetramethylpyrazine Conjugate DT-010 Overcomes Multidrug Resistance in Human Breast Cancer Journal article
FRONTIERS IN PHARMACOLOGY, 2019,Volume: 10
Authors:  Xinhua Zhou;  Anqi Wang;  Liang Wang;  Jianhua Yin;  Li Wang;  Lijun Di;  Maggie Pui-Man Hoi;  Luchen Shan;  Xu Wu;  Yuqiang Wang
Favorite |  | TC[WOS]:13 TC[Scopus]:13 | Submit date:2020/05/21
Danshensu  Tetramethylpyrazine  Breast Cancer  Resistance  Glycolysis  P-glycoprotein  
A novel agent attenuates cardiotoxicity and improves antitumor activity of doxorubicin in breast cancer cells Journal article
JOURNAL OF CELLULAR BIOCHEMISTRY, 2019,Volume: 120,Issue: 4,Page: 5913-5922
Authors:  Ying Zhang;  Hongkuan Deng;  Hefeng Zhou;  Yucong Lu;  Luchen Shan;  Simon Ming‐Yuen Lee;  Guozhen Cui
Favorite |  | TC[WOS]:10 TC[Scopus]:11 | Submit date:2020/01/16
Antitumor  Biotin-conjugated Adtm Analog (Baa)  Cardioprotection  Cardiotoxicity  Doxorubicin (Dox)  
A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor Journal article
FRONTIERS IN PHARMACOLOGY, 2018,Volume: 9
Authors:  Hu, Shengquan;  Hu, Huihui;  Mak, Shinghung;  Cui, Guozhen;  Lee, Mingyuen;  Shan, Luchen;  Wang, Yuqiang;  Lin, Huangquan;  Zhang, Zaijun;  Han, Yifan
Favorite |  | TC[WOS]:13 TC[Scopus]:16 | Submit date:2018/10/30
Alzheimer's Disease  Tetramethylpyrazine Derivative  Nmda Receptor  Neuroprotection  Oxidative Stress  Gsk3 Beta  
A novel compound DT-010 protects against doxorubicin-induced cardiotoxicity in zebrafish and H9c2 cells by inhibiting reactive oxygen species-mediated apoptotic and autophagic pathways Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 820,Page: 86-96
Authors:  Tang, Fan;  Zhou, Xinhua;  Wang, Liang;  Shan, Luchen;  Li, Chuwen;  Zhou, Hefeng;  Lee, Simon Ming-Yuen;  Hoi, Maggie Pui-Man
Favorite |  | TC[WOS]:29 TC[Scopus]:28 | Submit date:2018/10/30
Cardioprotection  Anti-oxidative Stress  Anti-apoptosis  Autophagy Regulation  Zebrafish Cardiotoxicity  H9c2 Cardiomyocytes  
A New Danshensu Derivative Protects Against 6-Hydroxydopamine-Induced Neurotoxicity in Vitro and in Vivo Journal article
American Journal of Chinese Medicine, 2016,Volume: 44,Issue: 7,Page: 1349-1361
Authors:  Guozhen Cui;  Luchen Shan;  Yang Chen;  Hefeng Zhou;  Yuqiang Wang;  Simon Ming-Yuen Lee
Favorite |  | TC[WOS]:9 TC[Scopus]:9 | Submit date:2018/11/06
Anti-inflammation  Anti-oxidation  Danshensu Derivative  Neuroprotection  
A novel agent enhances the chemotherapeutic efficacy of doxorubicin in MCF-7 breast cancer cells Journal article
Frontiers in Pharmacology, 2016,Volume: 7,Issue: AUG
Authors:  Liang Wang;  Judy Y. Chan;  Xinhua Zhou;  Guozhen Cui;  Zhixiang Yan;  Li Wang;  Ru Yan;  Lijun Di;  Yuqiang Wang;  Maggie P. Hoi;  Luchen Shan;  Simon M. Lee
Favorite |  | TC[WOS]:12 TC[Scopus]:15 | Submit date:2018/11/06
Breast Cancer  Danshensu  Doxorubicin  Glycolysis  Grp78 Protein  Tetramethylpyrazine  
A novel agent exerts antitumor activity in breast cancer cells by targeting mitochondrial complex II Journal article
Oncotarget, 2016,Volume: 7,Issue: 22,Page: 32054-32064
Authors:  Liang Wang;  Xiaojing Zhang;  Guozhen Cui;  Judy Yuet-Wa Chan;  Li Wang;  Chuwen Li;  Luchen Shan;  Changjiang Xu;  Qingwen Zhang;  Yuqiang Wang;  Lijun Di;  Simon Ming-Yuen Lee
Favorite |  | TC[WOS]:28 TC[Scopus]:33 | Submit date:2018/11/06
Breast Cancer  Danshensu  Mitochondrial Complex Ii  Reactive Oxygen Species  Tetramethylpyrazine  
Relaxation effect of a novel Danshensu/tetramethylpyrazine derivative on rat mesenteric arteries Journal article
European Journal of Pharmacology, 2015,Volume: 761,Page: 153-160
Authors:  Rachel Wai-Sum Li;  C. Yang;  Luchen Shan;  Zaijun Zhang;  Yuqiang Wang;  Y.W. Kwan;  Simon M.Y. Lee;  Maggie P.M. Hoi;  S.W. Chan;  Alex Chun Cheung;  K.H. Cheung;  George P.H. Leung
Favorite |  | TC[WOS]:16 TC[Scopus]:16 | Submit date:2018/11/06
Calcium Channel  Danshensu Tetramethylpyrazine  Mesenteric Artery  Relaxation  
Identification of disulfide isomerase ERp57 as a target for small molecule cardioprotective agents Journal article
RSC Advances, 2015,Volume: 5,Issue: 91,Page: 74605-74610
Authors:  Guozhen Cui;  Luchen Shan;  Ivan Keung Chu;  Guohui Li;  George Pak Heng Leung;  Yuqiang Wang;  Yiu Wa KWAN;  Shun Wan CHAN;  Maggie Pui Man Hoi;  Simon Ming Yuen Lee
Favorite |  | TC[WOS]:11 TC[Scopus]:14 | Submit date:2018/11/06
A Novel Danshensu Derivative Prevents Cardiac Dysfunction and Improves the Chemotherapeutic Efficacy of Doxorubicin in Breast Cancer Cells Journal article
Journal of Cellular Biochemistry, 2015,Volume: 117,Issue: 1,Page: 94-105
Authors:  Liang Wang;  Xiaojing Zhang;  Judy Yuet‐Wa Chan;  Luchen Shan;  Guozhen Cui;  Qingbin Cui;  Yingfei Wang;  Jingjing Li;  Huanxian Chen;  Qingwen Zhang;  Pei Yu;  Yifan Han;  Yuqiang Wang;  Simon Ming‐Yuen Lee
Favorite |  | TC[WOS]:25 TC[Scopus]:27 | Submit date:2018/11/06
Breast Cancer  Cardiotoxicity  Doxorubicin  Mitochondrial Biogenesis