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Aurora kinase A inhibition induces synthetic lethality in SMAD4-deficient colorectal cancer cells via spindle assembly checkpoint activation Journal article
Oncogene, 2022,Volume: 41,Issue: 19,Page: 2734-2748
Authors:  Shi, Changxiang;  Tao, Shishi;  Ren, Guowen;  Yang, Eun Ju;  Shu, Xiaodong;  Mou, Pui Kei;  Liu, Yifan;  Dang, Yongjun;  Xu, Xiaoling;  Shim, Joong Sup
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/05/31
Natural products targeting cancer cell dependency Journal article
Journal of Antibiotics, 2021,Volume: 74,Issue: 10,Page: 677-686
Authors:  Shi, Changxiang;  Yang, Eun Ju;  Tao, Shishi;  Ren, Guowen;  Mou, Pui Kei;  Shim, Joong Sup
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2021/12/08
Aurora kinase A, a synthetic lethal target for precision cancer medicine Journal article
Experimental and Molecular Medicine, 2021,Volume: 53,Issue: 5,Page: 835-847
Authors:  Mou, Pui Kei;  Yang, Eun Ju;  Shi, Changxiang;  Ren, Guowen;  Tao, Shishi;  Shim, Joong Sup
Favorite |  | TC[WOS]:8 TC[Scopus]:7 | Submit date:2021/12/07
Bromodomain and extra-terminal motif (BET) inhibition is synthetic lethal with loss of SMAD4 in colorectal cancer cells via restoring the loss of MYC repression Journal article
Oncogene, 2021,Volume: 40,Issue: 5,Page: 937-950
Authors:  Shi,Changxiang;  Yang,Eun Ju;  Liu,Yifan;  Mou,Pui Kei;  Ren,Guowen;  Shim,Joong Sup
Favorite |  | TC[WOS]:7 TC[Scopus]:7 | Submit date:2021/03/04
Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics Journal article
Nature Communications, 2020,Volume: 11,Issue: 1
Authors:  Lyu,Junfang;  Yang,Eun Ju;  Zhang,Baoyuan;  Wu,Changjie;  Pardeshi,Lakhansing;  Shi,Changxiang;  Mou,Pui Kei;  Liu,Yifan;  Tan,Kaeling;  Shim,Joong Sup
Favorite |  | TC[WOS]:8 TC[Scopus]:9 | Submit date:2021/03/04
Histone acetyltransferase (HAT) P300/CBP inhibitors induce synthetic lethality in pten-deficient colorectal cancer cells through destabilizing AKT Journal article
International Journal of Biological Sciences, 2020,Volume: 16,Issue: 11,Page: 1774-1784
Authors:  Liu,Yifan;  Yang,Eun Ju;  Shi,Changxiang;  Mou,Pui Kei;  Zhang,Baoyuan;  Wu,Changjie;  Lyu,Junfang;  Shim,Joong Sup
Favorite |  | TC[WOS]:5 TC[Scopus]:6 | Submit date:2021/03/04
AKT  Anacardic acid  Histone acetyltransferases  Hsp70  PTEN  Synthetic lethality