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A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor Journal article
FRONTIERS IN PHARMACOLOGY, 2018,Volume: 9
Authors:  Hu, Shengquan;  Hu, Huihui;  Mak, Shinghung;  Cui, Guozhen;  Lee, Mingyuen;  Shan, Luchen;  Wang, Yuqiang;  Lin, Huangquan;  Zhang, Zaijun;  Han, Yifan
Favorite |  | TC[WOS]:13 TC[Scopus]:16 | Submit date:2018/10/30
Alzheimer's Disease  Tetramethylpyrazine Derivative  Nmda Receptor  Neuroprotection  Oxidative Stress  Gsk3 Beta  
Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B Journal article
NEUROPHARMACOLOGY, 2017,Volume: 126,Page: 12-24
Authors:  Guo, Baojian;  Hu, Shengquan;  Zheng, Chengyou;  Wang, Hongyu;  Luo, Fangcheng;  Li, Haitao;  Cui, Wei;  Yang, Xifei;  Cui, Guozhen;  Mak, Shinghung;  Choi, Tony Chung-Lit;  Ma, Edmond Dik-Lung;  Wang, Yuqiang;  Lee, Simon Ming Yuen;  Zhang, Zaijun;  Han, Yifan
View | Adobe PDF | Favorite |  | TC[WOS]:16 TC[Scopus]:18 | Submit date:2018/10/31
Parkinson's Disease  Su4312  Neuroprotection  Myocyte Enhancer Factor 2d  Monoamine Oxidase-b  
Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3 beta and the ERK Pathway Journal article
CELLULAR AND MOLECULAR NEUROBIOLOGY, 2017,Volume: 37,Issue: 4,Page: 655-664
Authors:  Yu, Jie;  Zheng, Jiacheng;  Lin, Jiajia;  Jin, Linlu;  Yu, Rui;  Mak, Shinghung;  Hu, Shengquan;  Sun, Hongya;  Wu, Xiang;  Zhang, Zaijun;  Lee, Mingyuen;  Tsim, Wahkeung;  Su, Wei;  Zhou, Wenhua;  Cui, Wei;  Han, Yifan;  Wang, Qinwen
Favorite |  | TC[WOS]:18 TC[Scopus]:20 | Submit date:2018/10/30
Indirubin-3-oxime  H2o2  Gsk3 Beta  Pi3-k  Erk  
Potent Protection Against MPP+ -Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine Journal article
NEUROMOLECULAR MEDICINE, 2016,Volume: 18,Issue: 4,Page: 561-572
Authors:  Shengquan Hu;  Liang Wang;  Shinghung Mak;  Zaijun Zhang;  Daping Xu;  Haitao Li;  Yide Li;  Yuanjia Hu;  Simon Ming Yuen Lee;  Yuqiang Wang;  Yifan Han
Favorite |  | TC[WOS]:7 TC[Scopus]:7 | Submit date:2020/01/16
Parkinson’s Disease  Mef2d  Neuroprotection  
Potent Protection Against MPP+-Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine Journal article
NEUROMOLECULAR MEDICINE, 2016
Authors:  Hu, Shengquan;  Wang, Liang;  Mak, Shinghung;  Zhang, Zaijun;  Xu, Daping;  Li, Haitao;  Li, Yide;  Hu, Yuanjia;  Lee, Simon Ming Yuen;  Wang, Yuqiang;  Han, Yifan
Favorite |  | TC[WOS]:7 TC[Scopus]:0 | Submit date:2022/08/31
Substantial Neuroprotective and Neurite Outgrowth-Promoting Activities by Bis(propyl)-cognitin via the Activation of Alpha7-nAChR, a Promising Anti-Alzheimer's Dimer Journal article
ACS Chemical Neuroscience, 2015,Volume: 6,Issue: 9,Page: 1536-1545
Authors:  Shengquan Hu;  Wei Cui;  Shinghung Mak;  Daping Xu;  Yuanjia Hu;  Jing Tang;  Chunglit Choi;  Mingyuen Lee;  Yuanping Pang;  Yifan Han
Favorite |  | TC[WOS]:21 TC[Scopus]:21 | Submit date:2018/11/06
Alpha7-nicotinic Acetylcholine Receptor  Alzheimer's Disease  Bis(Propyl)-cognitin  Extracellular Signal-regulated Kinase  Neurite Outgrowth  Neuroprotection  
Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells via Activating MEF2D Through the Inhibition of GSK3β Journal article
Journal of Molecular Neuroscience, 2015,Volume: 57,Issue: 4,Page: 561–570
Authors:  Shengquan Hu;  Wei Cui;  Zaijun Zhang;  Shinghung Mak;  Daping Xu;  Gang Li;  Yuanjia Hu;  Yuqiang Wang;  Mingyuen Lee;  Karl Wahkeung Tsim;  Yifan Han
Favorite |  | TC[WOS]:22 TC[Scopus]:25 | Submit date:2018/10/30
6ohda  Gsk3β  Indirubin-3-oxime  Mef2d  Neuroprotection  Parkinson’s Disease  
Inhibiting β-Amyloid-Associated Alzheimer’s Pathogenesis In Vitro and In Vivo by a Multifunctional Dimeric Bis(12)-hupyridone Derived from Its Natural Analogue Journal article
Journal of Molecular Neuroscience, 2015,Volume: 55,Issue: 4,Page: 1014
Authors:  Shengquan Hu;  Rui Wang;  Wei Cui;  Zaijun Zhang;  Shinghung Mak;  Daping Xu;  Chunglit Choi;  Karl Wahkeung Tsim;  Paul R. Carlier;  Mingyuen Lee;  Yifan Han
Favorite |  | TC[WOS]:15 TC[Scopus]:15 | Submit date:2018/10/30
Alzheimer’s Disease  Aβ Fibrils  Bis(12)-hupyridone  Cell Viability  Memory Impairment  Thioflavin t  
Unexpected Neuronal Protection of SU5416 against 1-Methyl-4-Phenylpyridinium Ion-Induced Toxicity via Inhibiting Neuronal Nitric Oxide Synthase Journal article
PLoS ONE, 2012,Volume: 7,Issue: 9
Authors:  Wei Cui;  Zaijun Zhang;  Wenming Li;  Shinghung Mak;  Shengquan Hu;  Huan Zhang;  Shuai Yuan;  Jianhui Rong;  Tony Chunglit Choi;  Simon M. Y. Lee;  Yifan Han
Favorite |  | TC[WOS]:19 TC[Scopus]:23 | Submit date:2018/11/06
Bis(12)-hupyridone, a promising multi-functional anti-Alzheimer’s dimer derived from Chinese medicine Book chapter
出自: When Things Go Wrong - Diseases and Disorders of the Human Brain:InTech, 2012
Authors:  Wei Cui;  Tony Chung-Lit Choi;  Shinghung Mak;  Hua Yu;  Shengquan Hu;  Wenming Li;  Zhong Zuo
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2019/01/25