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Natural products targeting cancer cell dependency Journal article
Journal of Antibiotics, 2021,Volume: 74,Issue: 10,Page: 677-686
Authors:  Shi, Changxiang;  Yang, Eun Ju;  Tao, Shishi;  Ren, Guowen;  Mou, Pui Kei;  Shim, Joong Sup
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date：2021/12/08
Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa Journal article
eLife, 2021,Volume: 10
Authors:  Zhang, Liyun;  Chen, Conan;  Fu, Jie;  Lilley, Brendan;  Berlinicke, Cynthia;  Hansen, Baranda;  Ding, Ding;  Wang, Guohua;  Wang, Tao;  Shou, Daniel;  Ye, Ying;  Mulligan, Timothy;  Emmerich, Kevin;  Saxena, Meera T.;  Hall, Kelsi R.;  Sharrock, Abigail V.;  Brandon, Carlene;  Park, Hyejin;  Kam, Tae In;  Dawson, Valina L.;  Dawson, Ted M.;  Shim, Joong Sup;  Hanes, Justin;  Ji, Hongkai;  Liu, Jun O.;  Qian, Jiang;  Ackerley, David F.;  Rohrer, Baerbel;  Zack, Donald J.;  Mumm, Jeff S.
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date：2021/12/08
Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics Journal article
Nature Communications, 2021,Volume: 12,Issue: 1
Authors:  Ding, Ren Bo;  Chen, Ping;  Rajendran, Barani Kumar;  Lyu, Xueying;  Wang, Haitao;  Bao, Jiaolin;  Zeng, Jianming;  Hao, Wenhui;  Sun, Heng;  Wong, Ada Hang Heng;  Valecha, Monica Vishnu;  Yang, Eun Ju;  Su, Sek Man;  Choi, Tak Kan;  Liu, Shuiming;  Chan, Kin Iong;  Yang, Ling Lin;  Wu, Jingbo;  Miao, Kai;  Chen, Qiang;  Shim, Joong Sup;  Xu, Xiaoling;  Deng, Chu Xia
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date：2021/11/30
Aurora kinase A, a synthetic lethal target for precision cancer medicine Journal article
Experimental and Molecular Medicine, 2021,Volume: 53,Issue: 5,Page: 835-847
Authors:  Mou, Pui Kei;  Yang, Eun Ju;  Shi, Changxiang;  Ren, Guowen;  Tao, Shishi;  Shim, Joong Sup
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date：2021/12/07
Bromodomain and extra-terminal motif (BET) inhibition is synthetic lethal with loss of SMAD4 in colorectal cancer cells via restoring the loss of MYC repression Journal article
Oncogene, 2021,Volume: 40,Issue: 5,Page: 937-950
Authors:  Shi,Changxiang;  Yang,Eun Ju;  Liu,Yifan;  Mou,Pui Kei;  Ren,Guowen;  Shim,Joong Sup
Favorite |  | TC[WOS]:4 TC[Scopus]:5 | Submit date：2021/03/04
Ring Expansion Leads to a More Potent Analogue of Ipomoeassin F Journal article
Journal of Organic Chemistry, 2020,Volume: 85,Issue: 24,Page: 16226-16235
Authors:  Zong,Guanghui;  Hu,Zhijian;  Duah,Kwabena Baffour;  Andrews,Lauren E.;  Zhou,Jianhong;  O'Keefe,Sarah;  Whisenhunt,Lucas;  Shim,Joong Sup;  Du,Yuchun;  High,Stephen;  Shi,Wei Q.
Favorite |  | TC[WOS]:7 TC[Scopus]:7 | Submit date：2021/03/04
Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics Journal article
Nature Communications, 2020,Volume: 11,Issue: 1
Authors:  Lyu,Junfang;  Yang,Eun Ju;  Zhang,Baoyuan;  Wu,Changjie;  Pardeshi,Lakhansing;  Shi,Changxiang;  Mou,Pui Kei;  Liu,Yifan;  Tan,Kaeling;  Shim,Joong Sup
Favorite |  | TC[WOS]:7 TC[Scopus]:8 | Submit date：2021/03/04
Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells Journal article
Acta Pharmaceutica Sinica B, 2020,Volume: 10,Issue: 4,Page: 615-627
Authors:  Zhang,Baoyuan;  Lyu,Junfang;  Yang,Eun Ju;  Liu,Yifan;  Wu,Changjie;  Pardeshi,Lakhansing;  Tan,Kaeling;  Chen,Qiang;  Xu,Xiaoling;  Deng,Chu Xia;  Shim,Joong Sup
Favorite |  | TC[WOS]:14 TC[Scopus]:17 | Submit date：2020/09/16
Brca1  Breast Cancer  Dna Damage  Hdac  Histone Deacetylase  Reactive Oxygen Species  Synthetic Lethality  
Histone acetyltransferase (HAT) P300/CBP inhibitors induce synthetic lethality in pten-deficient colorectal cancer cells through destabilizing AKT Journal article
International Journal of Biological Sciences, 2020,Volume: 16,Issue: 11,Page: 1774-1784
Authors:  Liu，Yifan;  Yang，Eun Ju;  Shi，Changxiang;  Mou，Pui Kei;  Zhang，Baoyuan;  Wu，Changjie;  Lyu，Junfang;  Shim，Joong Sup
Favorite |  | TC[WOS]:5 TC[Scopus]:5 | Submit date：2021/03/04
AKT  Anacardic acid  Histone acetyltransferases  Hsp70  PTEN  Synthetic lethality  
Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein Journal article
Autophagy, 2020
Authors:  Hwang，Hui Yun;  Shim，Joong Sup;  Kim，Dasol;  Kwon，Ho Jeong
Favorite |  | TC[WOS]:11 TC[Scopus]:6 | Submit date：2021/03/04
AMPK  antidepressant  darts  MAPT  MTOR  Sert  tauopathy  VDAC1