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Bromodomain and extra-terminal motif (BET) inhibition is synthetic lethal with loss of SMAD4 in colorectal cancer cells via restoring the loss of MYC repression Journal article
Oncogene, 2021,Volume: 40,Issue: 5,Page: 937-950
Authors:  Shi,Changxiang;  Yang,Eun Ju;  Liu,Yifan;  Mou,Pui Kei;  Ren,Guowen;  Shim,Joong Sup
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2021/03/04
Ring Expansion Leads to a More Potent Analogue of Ipomoeassin F Journal article
Journal of Organic Chemistry, 2020,Volume: 85,Issue: 24,Page: 16226-16235
Authors:  Zong,Guanghui;  Hu,Zhijian;  Duah,Kwabena Baffour;  Andrews,Lauren E.;  Zhou,Jianhong;  O'Keefe,Sarah;  Whisenhunt,Lucas;  Shim,Joong Sup;  Du,Yuchun;  High,Stephen;  Shi,Wei Q.
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2021/03/04
Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics Journal article
Nature Communications, 2020,Volume: 11,Issue: 1
Authors:  Lyu,Junfang;  Yang,Eun Ju;  Zhang,Baoyuan;  Wu,Changjie;  Pardeshi,Lakhansing;  Shi,Changxiang;  Mou,Pui Kei;  Liu,Yifan;  Tan,Kaeling;  Shim,Joong Sup
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2021/03/04
Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells Journal article
Acta Pharmaceutica Sinica B, 2020,Volume: 10,Issue: 4,Page: 615-627
Authors:  Zhang,Baoyuan;  Lyu,Junfang;  Yang,Eun Ju;  Liu,Yifan;  Wu,Changjie;  Pardeshi,Lakhansing;  Tan,Kaeling;  Chen,Qiang;  Xu,Xiaoling;  Deng,Chu Xia;  Shim,Joong Sup
Favorite |  | TC[WOS]:11 TC[Scopus]:12 | Submit date:2020/09/16
Brca1  Breast Cancer  Dna Damage  Hdac  Histone Deacetylase  Reactive Oxygen Species  Synthetic Lethality  
Histone acetyltransferase (HAT) P300/CBP inhibitors induce synthetic lethality in pten-deficient colorectal cancer cells through destabilizing AKT Journal article
International Journal of Biological Sciences, 2020,Volume: 16,Issue: 11,Page: 1774-1784
Authors:  Liu,Yifan;  Yang,Eun Ju;  Shi,Changxiang;  Mou,Pui Kei;  Zhang,Baoyuan;  Wu,Changjie;  Lyu,Junfang;  Shim,Joong Sup
Favorite |  | TC[WOS]:5 TC[Scopus]:4 | Submit date:2021/03/04
AKT  Anacardic acid  Histone acetyltransferases  Hsp70  PTEN  Synthetic lethality  
Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein Journal article
Autophagy, 2020
Authors:  Hwang,Hui Yun;  Shim,Joong Sup;  Kim,Dasol;  Kwon,Ho Jeong
Favorite |  | TC[WOS]:7 TC[Scopus]:8 | Submit date:2021/03/04
AMPK  antidepressant  darts  MAPT  MTOR  Sert  tauopathy  VDAC1  
Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells Journal article
NATURE COMMUNICATIONS, 2018,Volume: 9
Authors:  Wu, Changjie;  Lyu, Junfang;  Yang, Eun Ju;  Liu, Yifan;  Zhang, Baoyuan;  Shim, Joong Sup
Favorite |  | TC[WOS]:34 TC[Scopus]:33 | Submit date:2018/10/30
Astemizole inhibits mTOR signaling and angiogenesis by blocking cholesterol trafficking Journal article
International Journal of Biological Sciences, 2018,Volume: 14,Issue: 10,Page: 1175-1185
Authors:  Lyu,Junfang;  Yang,Eun Ju;  Head,Sarah A.;  Ai,Nana;  Zhang,Baoyuan;  Wu,Changjie;  Li,Ruo Jing;  Liu,Yifan;  Chakravarty,Harapriya;  Zhang,Shaolin;  Tam,Kin Yip;  Dang,Yongjun;  Kwon,Ho Jeong;  Ge,Wei;  Liu,Jun O.;  Shim,Joong Sup
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2021/03/02
Angiogenesis  Astemizole  Cholesterol trafficking  mTOR  NPC1  
Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking Journal article
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2018,Volume: 14,Issue: 10,Page: 1175-1185
Authors:  Lyu, Junfang;  Yang, Eun Ju;  Head, Sarah A.;  Ai, Nana;  Zhang, Baoyuan;  Wu, Changjie;  Li, Ruo-Jing;  Liu, Yifan;  Chakravarty, Harapriya;  Zhang, Shaolin;  Tam, Kin Yip;  Dang, Yongjun;  Kwon, Ho Jeong;  Gel, Wei;  Liu, Jun O.;  Shim, Joong Sup
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2018/10/30
Cholesterol Trafficking  Angiogenesis  Astemizole  Npc1  Mtor  
Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth Journal article
CANCER LETTERS, 2017,Volume: 409,Page: 91-103
Authors:  Lyu, Junfang;  Yang, Eun Ju;  Head, Sarah A.;  Ai, Nana;  Zhang, Baoyuan;  Wu, Changjie;  Li, Ruo-Jing;  Liu, Yifan;  Yang, Chen;  Dang, Yongjun;  Kwon, Ho Jeong;  Ge, Wei;  Liu, Jun O.;  Shim, Joong Sup
Favorite |  | TC[WOS]:28 TC[Scopus]:25 | Submit date:2018/10/30
Cholesterol Trafficking  Angiogenesis  Tumor  Lysosome  Cepharanthine