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The oral manifestations and related mechanisms of COVID-19 caused by SARS-CoV-2 infection Journal article
Frontiers in Cellular Neuroscience, 2023,Volume: 16
Authors:  Lin, Weiming;  Gao, Feng;  Wang, Xia;  Qin, Nianhong;  Chen, Xianxiong;  Tam, Kin Yip;  Zhang, Chengfei;  Zhang, Mingxia;  Sha, Ou
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2023/02/08
ACE2 receptor  COVID-19  influential factors  oral manifestations  SARS-CoV-2  TMPRSS2  
Trichosanthin Promotes Anti-Tumor Immunity through Mediating Chemokines and Granzyme B Secretion in Hepatocellular Carcinoma Journal article
International Journal of Molecular Sciences, 2023,Volume: 24,Issue: 2
Authors:  Wang, Kaifang;  Wang, Xiaona;  Zhang, Minghuan;  Ying, Zhenguang;  Zhu, Zeyao;  Tam, Kin Yip;  Li, Chunman;  Zhou, Guowei;  Gao, Feng;  Zeng, Meiqi;  Sze, Stephen Cho Wing;  Wang, Xia;  Sha, Ou
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2023/02/08
apoptosis  chemokine  Granzyme B (GrzB)  hepatocellular carcinoma (HCC)  T cell  Trichosanthin (TCS)  
The interaction between E3 ubiquitin ligase Parkin and mitophagy receptor PHB2 links inner mitochondrial membrane ubiquitination to efficient mitophagy Journal article
Journal of Biological Chemistry, 2022,Volume: 298,Issue: 12
Authors:  Sun, Shan;  Hou, Hongyu;  Ma, Guoqiang;  Ma, Qilian;  Li, Ningning;  Zhang, Li;  Dong, Chunsheng;  Cao, Mian;  Tam, Kin Yip;  Ying, Zheng;  Wang, Hongfeng
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2023/01/30
Map1lc3b/lc3b  Mitophagy  Parkin  Phb2  Ubiquitination  
Targeting glucose metabolism to develop anticancer treatments and therapeutic patents Journal article
Expert Opinion on Therapeutic Patents, 2022,Volume: 32,Issue: 4,Page: 441-453
Authors:  Zhou, Yan;  Guo, Yizhen;  Tam, Kin Yip
Favorite |  | TC[WOS]:8 TC[Scopus]:7 | Submit date:2022/05/17
Cancer Glucose Metabolism  Cancer Treatment Patent  Glycolytic Inhibitor  Hexokinase 2 (Hk2)  Lactate Dehydrogenase a (Ldha)  Pyruvate Dehydrogenase Kinase (Pdk)  Warburg Effect  
Pathological mechanisms and therapeutic strategies for Alzheimer's disease Journal article
Neural Regeneration Research, 2022,Volume: 17,Issue: 3,Page: 543-549
Authors:  Ju, Yaojun;  Tam, Kin
Favorite |  | TC[WOS]:51 TC[Scopus]:53 | Submit date:2022/03/28
Alzheimer's Disease  Drug Development  Multiple Pathologies  Pathological Pathways  
The development of small-molecule inhibitors targeting hexokinase 2 Journal article
Drug Discovery Today, 2022,Volume: 27,Issue: 9,Page: 2574-2585
Authors:  Shan, Wenying;  Zhou, Yan;  Tam, Kin Yip
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2022/08/05
Cancer Metabolism  Drug–target Binding  Hexokinase 2  Selective Inhibition  Structure-based Molecular Design  
Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity Journal article
European Journal of Medicinal Chemistry, 2021,Volume: 214
Authors:  Xu,Biao;  Wang,Zhi Peng;  Liu,Qingwang;  Yang,Xiaohong;  Li,Xuemin;  Huang,Ding;  Qiu,Yanfei;  Tam,Kin Yip;  Zhang,Shao Lin;  He,Yun
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2021/03/04
Cancer Metabolism  Proliferation  Pyruvate Dehydrogenase Kinase  Structure-activity Relationship  
Recent developments of human monocarboxylate transporter (hMCT) inhibitors as anticancer agents Journal article
Drug Discovery Today, 2021
Authors:  Wu,Puhua;  Zhou,Yan;  Guo,Yizhen;  Zhang,Shao Lin;  Tam,Kin Yip
Favorite |  | TC[WOS]:5 TC[Scopus]:4 | Submit date:2021/03/04
Metabolic reprogramming of ovarian cancer involves ACSL1-mediated metastasis stimulation through upregulated protein myristoylation Journal article
Oncogene, 2021,Volume: 40,Issue: 1,Page: 97-111
Authors:  Zhang,Qingyu;  Zhou,Wei;  Yu,Shan;  Ju,Yaojun;  To,Sally Kit Yan;  Wong,Alice Sze Tsai;  Jiao,Yufei;  Poon,Terence Chuen Wai;  Tam,Kin Yip;  Lee,Leo Tsz On
Favorite |  | TC[WOS]:15 TC[Scopus]:16 | Submit date:2021/03/04
9R, the cholinesterase and amyloid beta aggregation dual inhibitor, as a multifunctional agent to improve cognitive deficit and neuropathology in the triple-transgenic Alzheimer's disease mouse model Journal article
Neuropharmacology, 2020,Volume: 181
Authors:  Ju,Yaojun;  Tam,Kin Yip
Favorite |  | TC[WOS]:5 TC[Scopus]:5 | Submit date:2021/03/04
Alzheimer's Disease  Amyloid Beta  Cholinesterase  Dual Inhibition  Multifunction