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Targeting glucose metabolism to develop anticancer treatments and therapeutic patents Journal article
Expert Opinion on Therapeutic Patents, 2022,Volume: 32,Issue: 4,Page: 441-453
Authors:  Zhou, Yan;  Guo, Yizhen;  Tam, Kin Yip
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date:2022/05/17
Cancer Glucose Metabolism  Cancer Treatment Patent  Glycolytic Inhibitor  Hexokinase 2 (Hk2)  Lactate Dehydrogenase a (Ldha)  Pyruvate Dehydrogenase Kinase (Pdk)  Warburg Effect  
The development of small-molecule inhibitors targeting hexokinase 2 Journal article
Drug Discovery Today, 2022
Authors:  Shan, Wenying;  Zhou, Yan;  Tam, Kin Yip
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/08/05
Cancer metabolism  Drug–target binding  Hexokinase 2  Selective inhibition  Structure-based molecular design  
Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity Journal article
European Journal of Medicinal Chemistry, 2021,Volume: 214
Authors:  Xu,Biao;  Wang,Zhi Peng;  Liu,Qingwang;  Yang,Xiaohong;  Li,Xuemin;  Huang,Ding;  Qiu,Yanfei;  Tam,Kin Yip;  Zhang,Shao Lin;  He,Yun
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date:2021/03/04
Cancer Metabolism  Proliferation  Pyruvate Dehydrogenase Kinase  Structure-activity Relationship  
Recent developments of human monocarboxylate transporter (hMCT) inhibitors as anticancer agents Journal article
Drug Discovery Today, 2021
Authors:  Wu,Puhua;  Zhou,Yan;  Guo,Yizhen;  Zhang,Shao Lin;  Tam,Kin Yip
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date:2021/03/04
Metabolic reprogramming of ovarian cancer involves ACSL1-mediated metastasis stimulation through upregulated protein myristoylation Journal article
Oncogene, 2021,Volume: 40,Issue: 1,Page: 97-111
Authors:  Zhang,Qingyu;  Zhou,Wei;  Yu,Shan;  Ju,Yaojun;  To,Sally Kit Yan;  Wong,Alice Sze Tsai;  Jiao,Yufei;  Poon,Terence Chuen Wai;  Tam,Kin Yip;  Lee,Leo Tsz On
Favorite |  | TC[WOS]:8 TC[Scopus]:10 | Submit date:2021/03/04
9R, the cholinesterase and amyloid beta aggregation dual inhibitor, as a multifunctional agent to improve cognitive deficit and neuropathology in the triple-transgenic Alzheimer's disease mouse model Journal article
Neuropharmacology, 2020,Volume: 181
Authors:  Ju,Yaojun;  Tam,Kin Yip
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2021/03/04
Alzheimer's Disease  Amyloid Beta  Cholinesterase  Dual Inhibition  Multifunction  
An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer's Disease Journal article
ACS Chemical Neuroscience, 2020,Volume: 11,Issue: 20,Page: 3346-3357
Authors:  Ju,Yaojun;  Chakravarty,Harapriya;  Tam,Kin Yip
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date:2021/03/04
Alzheimer's Disease  Amyloid Beta  Cholinesterase  Dual Inhibition  
Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation Journal article
European Journal of Medicinal Chemistry, 2020,Volume: 203
Authors:  Xiang,Sichuan;  Huang,Ding;  He,Qiaolin;  Li,Jie;  Tam,Kin Yip;  Zhang,Shao Lin;  He,Yun
Favorite |  | TC[WOS]:5 TC[Scopus]:5 | Submit date:2021/03/04
Cancer Metabolism  Cancer Proliferation  Dual Inhibitor  Lactate Dehydrogenase a  Pyruvate Dehydrogenase Kinase  
Synthesis and biological effect of lysosome-targeting fluorescent anion transporters with enhanced anionophoric activity Journal article
Bioorganic and Medicinal Chemistry Letters, 2020,Volume: 30,Issue: 19
Authors:  Hong,Xiao Qiao;  He,Xiang Yu;  Tam,Kin Yip;  Chen,Wen Hua
Favorite |  | TC[WOS]:5 TC[Scopus]:5 | Submit date:2021/03/04
Cathepsin b Enzyme  Fluorescent Anion Transporter  Lysosomal Alkalization  Lysosome Targeting  
Novel Therapeutic Anti-ADAM17 Antibody A9(B8) Enhances EGFR-TKI–Mediated Anticancer Activity in NSCLC Journal article
Translational Oncology, 2019,Volume: 12,Issue: 11,Page: 1516-1524
Authors:  Yang,Zheng;  Chan,Kin Iong;  Kwok,Hang Fai;  Tam,Kin Yip
Favorite |  | TC[WOS]:6 TC[Scopus]:5 | Submit date:2021/03/04