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A Mitochondria-Targeted Phenylbutyric Acid Prodrug Confers Drastically Improved Anticancer Activities Journal article
Journal of Medicinal Chemistry, 2022,Volume: 65,Page: 9955-9973
Authors:  D. Huang;  Q. Liu;  M. Zhang;  Y. Gao;  Z. Cui;  T. Li;  D. Luo;  B. Xu;  C. Huang;  J. Guo;  K.Y. Tam;  M. Zhang;  S.L. Zhang;  Y. He
Favorite |  | TC[WOS]:0 TC[Scopus]:1 | Submit date:2022/08/28
Anti-neuroinflammatory effects of SLOH in Aβ-induced BV-2 microglial cells and 3xTg-AD mice involve the inhibition of GSK-3β Journal article
Neuroscience Letters, 2018,Volume: 687,Page: 207-215
Authors:  Wu X.;  Kosaraju J.;  Tam K.Y.
Favorite |  | TC[WOS]:7 TC[Scopus]:6 | Submit date:2018/12/18
3xTg-AD mice  BV-2 cells  GSK-3β  Neuroinflammation  SLOH  
Identification of Novel Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors by Kinase Activity-Based High-Throughput Screening for Anticancer Therapeutics Journal article
ACS Combinatorial Science, 2018,Volume: 20,Issue: 11,Page: 660-671
Authors:  Zhang W.;  Hu X.;  Chakravarty H.;  Yang Z.;  Tam K.Y.
Favorite |  | TC[WOS]:7 TC[Scopus]:7 | Submit date:2018/12/18
cancer  high-throughput screening  pyruvate dehydrogenase kinase 1  small molecule inhibitors  Warburg effect  
Identification of a Wells-Dawson polyoxometalatebased AP-2γ inhibitor with pro-apoptotic activity Journal article
Biochemical Journal, 2018,Volume: 475,Issue: 11,Page: 1965-1977
Authors:  Hu J.;  Tan S.K.;  Lim M.G.L.;  Chang S.H.;  Cui G.;  Liu S.;  Narasimhan K.;  New S.Y.;  Wang X.;  Chen C.;  Chakravarty H.;  Kolatkar P.R.;  Tam K.Y.;  Lu Q.;  Su X.;  Jauch R.;  Cheung E.
Favorite |  | TC[WOS]:5 TC[Scopus]:5 | Submit date:2018/12/17
Geniposide improves insulin production and reduces apoptosis in high glucose-induced glucotoxic insulinoma cells Journal article
European Journal of Pharmaceutical Sciences, 2017,Volume: 110,Page: 70-76
Authors:  Guo L.X.;  Liu J.H.;  Zheng X.X.;  Yin Z.Y.;  Kosaraju J.;  Tam K.Y.
Favorite |  | TC[WOS]:16 TC[Scopus]:20 | Submit date:2018/12/18
Apoptosis  Geniposide  Glucose-stimulated Insulin Secretion  Glucotoxicity  
Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells Journal article
European Journal of Pharmaceutical Sciences, 2017,Volume: 110,Page: 87-92
Authors:  Zhang S.-L.;  Zhang W.;  Yang Z.;  Hu X.;  Tam K.Y.
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2018/12/18
Anti-proliferation  Binding Affinity  Pyruvate Dehydrogenase Complex  Pyruvate Dehydrogenase Kinase  
SLM, a novel carbazole-based fluorophore attenuates okadaic acid-induced tau hyperphosphorylation via down-regulating GSK-3β activity in SH-SY5Y cells Journal article
European Journal of Pharmaceutical Sciences, 2017,Volume: 110,Page: 101-108
Authors:  Wu X.;  Kosaraju J.;  Tam K.Y.
Favorite |  | TC[WOS]:11 TC[Scopus]:10 | Submit date:2018/12/18
Alzheimer's Disease  Glycogen Synthase Kinase-3β  Okadaic Acid  Slm  Tau Hyperphosphorylation  
Neuroprotective Effect of SLM, a Novel Carbazole-Based Fluorophore, on SH-SY5Y Cell Model and 3xTg-AD Mouse Model of Alzheimer’s Disease Journal article
ACS Chemical Neuroscience, 2017,Volume: 8,Issue: 3,Page: 676-685
Authors:  Wu X.;  Kosaraju J.;  Zhou W.;  Tam K.Y.
Favorite |  | TC[WOS]:18 TC[Scopus]:18 | Submit date:2018/12/18
3xtg-ad  Aggregation  Alzheimer’s Disease  Amyloid β  Neuroprotection  Sh-sy5y  Slm  
Association of vancomycin with lipid vesicles Journal article
ADMET and DMPK, 2017,Volume: 5,Issue: 3,Page: 182-191
Authors:  Hu X.;  Tam K.Y.
Favorite |  | TC[WOS]:2 TC[Scopus]:1 | Submit date:2018/12/18
Antibiotics  Binding  Liposome  Membrane  Phospholipids  
How Ethnic Minority Students Perceive Patterns in Chinese Characters: Knowledge of Character Components and Structures Book chapter
出自: CHINESE AS A SECOND LANGUAGE ASSESSMENT:SPRINGER-VERLAG SINGAPORE PTE LTD, 2017, 页码: 91-113
Authors:  Elizabeth K.Y. Loh;  Loretta C.W. Tam;  Cally P.T. Lau;  Shing On Leung
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date:2018/10/30
Chinese As a Second Language (Csl)  Ethnic Minority (Em) Students  Orthographic Awareness  Chinese Character Components  Learning Strategies