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TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2 Journal article
Acta Pharmacologica Sinica, 2022,Volume: 43,Issue: 5,Page: 1251-1263
Authors:  Yang, Chuan bin;  Liu, Jia;  Tong, Benjamin Chun Kit;  Wang, Zi ying;  Zhu, Zhou;  Su, Cheng fu;  Sreenivasmurthy, Sravan Gopalkrishnashetty;  Wu, Jia xi;  Iyaswamy, Ashok;  Krishnamoorthi, Senthilkumar;  Huang, Shi ying;  Cheung, King ho;  Song, Ju xian;  Tan, Jie qiong;  Lu, Jia hong;  Li, Min
Favorite |  | TC[WOS]:1 TC[Scopus]:2 | Submit date：2022/05/13
15-deoxy-∆-12,14-prostaglandin J2 (15d-PGJ2)  apoptosis  ATF4  autophagy and lysosome biogenesis  ER stress  transcriptional factor EB (TFEB)  
Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition Journal article
Phytomedicine, 2022,Volume: 96
Authors:  Sreenivasmurthy, Sravan Gopalkrishnashetty;  Iyaswamy, Ashok;  Krishnamoorthi, Senthilkumar;  Senapati, Sanjib;  Malampati, Sandeep;  Zhu, Zhou;  Su, Cheng Fu;  Liu, Jia;  Guan, Xin Jie;  Tong, Benjamin Chun Kit;  Cheung, King Ho;  Tan, Jie Qiong;  Lu, Jia Hong;  Durairajan, Siva Sundara Kumar;  Song, Ju Xian;  Li, Min
Favorite |  | TC[WOS]:0 TC[Scopus]:3 | Submit date：2022/03/04
3xtg-ad Mice  Alzheimer's Disease  Hdac6  P301s-tau Mice  Phospho-tau  Protopine  
Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy Journal article
Acta Pharmacologica Sinica, 2022
Authors:  Zhu, Zhou;  Liu, Liang feng;  Su, Cheng fu;  Liu, Jia;  Tong, Benjamin Chun Kit;  Iyaswamy, Ashok;  Krishnamoorthi, Senthilkumar;  Sreenivasmurthy, Sravan Gopalkrishnashetty;  Guan, Xin jie;  Kan, Yu xuan;  Xie, Wen jian;  Zhao, Chen liang;  Cheung, King ho;  Lu, Jia hong;  Tan, Jie qiong;  Zhang, Hong jie;  Song, Ju xian;  Li, Min
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2022/05/17
autophagy  corynoxine B  dopaminergic neuron  MPP+  oxindole alkaloid  Parkinson’s disease  PI3P  PIK3C3 complex  
Lycorine, a natural alkaloid, promotes the degradation of alpha-synuclein via PKA-mediated UPS activation in transgenic Parkinson's disease models Journal article
Phytomedicine, 2021,Volume: 87
Authors:  Zhu, Qi;  Zhuang, Xu xu;  Chen, Jia yue;  Yuan, Ning ning;  Chen, Yan;  Cai, Cui zan;  Tan, Jie qiong;  Su, Huan xing;  Lu, Jia hong
Favorite |  | TC[WOS]:2 TC[Scopus]:1 | Submit date：2021/12/08
Camp/pka Pathway  Lycorine  Parkinson's Disease  Ubiquitin-proteasome System  Α-synuclein  
NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation Journal article
Autophagy, 2020,Volume: 17,Issue: 5,Page: 1112-1130
Authors:  Cai,Cui Zan;  Yang,Chuanbin;  Zhuang,Xu Xu;  Yuan,Ning Ning;  Wu,Ming Yue;  Tan,Jie Qiong;  Song,Ju Xian;  Cheung,King Ho;  Su,Huanxing;  Wang,Yi Tao;  Tang,Bei Sha;  Behrends,Christian;  Durairajan,Siva Sundara Kumar;  Yue,Zhenyu;  Li,Min;  Lu,Jia Hong
Favorite |  | TC[WOS]:9 TC[Scopus]:12 | Submit date：2021/03/01
Amaturation  Autophagy  Ccz1-mon1a  Nrbf2  Pi3kc3  Rab7  Trafficking  Vps34  
Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson’s disease models Journal article
Cell Death and Disease, 2020,Volume: 11,Issue: 2
Authors:  Zhuang,Xu Xu;  Wang,Sheng Fang;  Tan,Yuan;  Song,Ju Xian;  Zhu,Zhou;  Wang,Zi Ying;  Wu,Ming Yue;  Cai,Cui Zan;  Huang,Zhi Jian;  Tan,Jie Qiong;  Su,Huan Xing;  Li,Min;  Lu,Jia Hong
Favorite |  | TC[WOS]:34 TC[Scopus]:34 | Submit date：2021/03/01
Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation Journal article
Phytomedicine, 2019,Volume: 61
Authors:  Cai,Cui Zan;  Zhou,He Feng;  Yuan,Ning Ning;  Wu,Ming Yue;  Lee,Simon Ming Yuen;  Ren,Jiao Yan;  Su,Huan Xing;  Lu,Jin Jian;  Chen,Xiu Ping;  Li,Min;  Tan,Jie Qiong;  Lu,Jia Hong
Favorite |  | TC[WOS]:15 TC[Scopus]:17 | Submit date：2021/03/01
-synuclein  Harmine  Parkinson's Disease  Protein Kinase a  Ubiquitin-proteasome System  
High content screening for drug discovery from traditional Chinese medicine Journal article
Chinese Medicine (United Kingdom), 2019,Volume: 14,Issue: 1
Authors:  Wang,Jing;  Wu,Ming Yue;  Tan,Jie Qiong;  Li,Min;  Lu,Jia Hong
Favorite |  | TC[WOS]:11 TC[Scopus]:11 | Submit date：2021/03/02
Advanced Models  Drug Discovery  High-content Screening  Progressive Instruments  Traditional Chinese Medicine  
Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology Journal article
FRONTIERS IN PHARMACOLOGY, 2019,Volume: 10
Authors:  Ning-Ning Yuan;  Cui-Zan Cai;  Ming-Yue Wu;  Qi Zhu;  HuanXing Su;  Min Li;  JiaoYan Ren;  Jie-Qiong Tan;  Jia-Hong Lu
Favorite |  | TC[WOS]:9 TC[Scopus]:12 | Submit date：2020/04/14
Canthin-6-one  Parkinson’s Disease  Alpha-synuclein  Ubiquitin-proteasome-system  Crispr/cas9  Rpn2/psmd1  Pka  
Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin-induced toxicity Journal article
ONCOTARGET, 2017,Volume: 8,Issue: 44,Page: 77673-77684
Authors:  Wu, Ming-Yue;  Wang, Sheng-Fang;  Cai, Cui-Zan;  Tan, Jie-Qiong;  Li, Min;  Lu, Jin-Jian;  Chen, Xiu-Ping;  Wang, Yi-Tao;  Zheng, Wei;  Lu, Jia-Hong
Favorite |  | TC[WOS]:19 TC[Scopus]:19 | Submit date：2018/10/30
Dauricine  Daurisoline  Autophagy Blocker  Cancer Cells  Cell Toxicity