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α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation Journal article
Phytomedicine, 2022,Volume: 101
Authors:  Chen, Jia Yue;  Zhu, Qi;  Cai, Cui Zan;  Luo, Hai Bin;  Lu, Jia Hong
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/05/31
Alpha-synuclein (Α-syn)  Parkinson's Disease  Phosphodiesterase 4 Inhibitor  Protein Kinase a (Pka)  Ubiquitin-proteasome System (Ups)  
USP13: Multiple Functions and Target Inhibition Journal article
Frontiers in Cell and Developmental Biology, 2022,Volume: 10
Authors:  Li, Xiaolong;  Yang, Ge;  Zhang, Wenyao;  Qin, Biying;  Ye, Zifan;  Shi, Huijing;  Zhao, Xinmeng;  Chen, Yihang;  Song, Bowei;  Mei, Ziqing;  Zhao, Qi;  Wang, Feng
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/05/04
Deubiquitination  Disease  Inhibitor  Structure  Ubiquitin-specific Protease 13  
USP15 in Cancer and Other Diseases: From Diverse Functionsto Therapeutic Targets Journal article
Biomedicines, 2022,Volume: 10,Issue: 2
Authors:  Li, Yan Chi;  Cai, Song Wang;  Shu, Yu Bin;  Chen, Mei Wan;  Shi, Zhi
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/03/04
Cancer  Deubiquitinatase  Target  Ubiquitin  Usp15  
Small molecules targeting ubiquitination to control inflammatory diseases Journal article
Drug Discovery Today, 2021,Volume: 26,Issue: 10,Page: 2414-2422
Authors:  Li, Zheng Qing;  Chen, Xiuping;  Wang, Ying
Favorite |  | TC[WOS]:1 TC[Scopus]:0 | Submit date:2021/12/08
Inflammatory Diseases  Small Molecule Modulator  Ubiquitin  Ubiquitination System  
Lycorine, a natural alkaloid, promotes the degradation of alpha-synuclein via PKA-mediated UPS activation in transgenic Parkinson's disease models Journal article
Phytomedicine, 2021,Volume: 87
Authors:  Zhu, Qi;  Zhuang, Xu xu;  Chen, Jia yue;  Yuan, Ning ning;  Chen, Yan;  Cai, Cui zan;  Tan, Jie qiong;  Su, Huan xing;  Lu, Jia hong
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2021/12/08
Camp/pka Pathway  Lycorine  Parkinson's Disease  Ubiquitin-proteasome System  Α-synuclein  
Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation Journal article
Phytomedicine, 2019,Volume: 61
Authors:  Cai,Cui Zan;  Zhou,He Feng;  Yuan,Ning Ning;  Wu,Ming Yue;  Lee,Simon Ming Yuen;  Ren,Jiao Yan;  Su,Huan Xing;  Lu,Jin Jian;  Chen,Xiu Ping;  Li,Min;  Tan,Jie Qiong;  Lu,Jia Hong
Favorite |  | TC[WOS]:18 TC[Scopus]:19 | Submit date:2021/03/01
-synuclein  Harmine  Parkinson's Disease  Protein Kinase a  Ubiquitin-proteasome System  
Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology Journal article
FRONTIERS IN PHARMACOLOGY, 2019,Volume: 10
Authors:  Ning-Ning Yuan;  Cui-Zan Cai;  Ming-Yue Wu;  Qi Zhu;  HuanXing Su;  Min Li;  JiaoYan Ren;  Jie-Qiong Tan;  Jia-Hong Lu
Favorite |  | TC[WOS]:10 TC[Scopus]:12 | Submit date:2020/04/14
Canthin-6-one  Parkinson’s Disease  Alpha-synuclein  Ubiquitin-proteasome-system  Crispr/cas9  Rpn2/psmd1  Pka  
The expression of ubiquitin-specific peptidase 8 and its prognostic role in patients with breast cancer Journal article
Journal of Cellular Biochemistry, 2018,Volume: 119,Issue: 12,Page: 10051-10058
Authors:  Qiu H.;  Kong J.;  Cheng Y.;  Li G.
Favorite |  | TC[WOS]:9 TC[Scopus]:10 | Submit date:2019/01/15
breast cancer  clinical prognosis  ubiquitin-specific peptidase 8  
Structure-based identification of a NEDD8-activating enzyme inhibitor via drug repurposing Journal article
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018,Volume: 143,Page: 1021-1027
Authors:  Wu, Ke-Jia;  Zhong, Hai-Jing;  Li, Guodong;  Liu, Chenfu;  Wang, Hui-Min David;  Ma, Dik-Lung;  Leung, Chung-Hang
Favorite |  | TC[WOS]:40 TC[Scopus]:40 | Submit date:2018/10/30
Drug Repurposing  Mitoxantrone  Nedd8  Ubiquitin  
Pulsatilla saponin D synergistically enhances anticancer activity of camptothecin via inhibition of autophagosome-lysosome fusion Conference paper
Hong Kong, 02-03/11/2017
Authors:  Wang, K;  Zhang, C;  Zhang, Y;  Jia, X;  Tu, Y;  He, C. W.
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/07/28
Pulsatilla Saponin d  Camptothecin  Autophagy  Lysosome  Ubiquitin  Breast Cancer Cells