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Tetramethylpyrazine Analogue T-006 Promotes the Clearance of Alpha-synuclein by Enhancing Proteasome Activity in Parkinson’s Disease Models Journal article
Neurotherapeutics, 2019,Volume: 16,Issue: 4,Page: 1225-1236
Authors:  Zhou，Hefeng;  Shao，Min;  Guo，Baojian;  Li，Chuwen;  Lu，Yucong;  Yang，Xuanjun;  ShengnanLi，;  Li，Haitao;  Zhu，Qi;  Zhong，Hanbing;  Wang，Yuqiang;  Zhang，Zaijun;  Lu，Jiahong;  Lee，Simon Ming Yuen
Favorite |  | TC[WOS]:7 TC[Scopus]:7 | Submit date：2021/03/01
Degradation  LMP7  Parkinson’s disease  Proteasome activity  α-synuclein  
A Danshensu-Tetramethylpyrazine Conjugate DT-010 Overcomes Multidrug Resistance in Human Breast Cancer Journal article
FRONTIERS IN PHARMACOLOGY, 2019,Volume: 10
Authors:  Xinhua Zhou;  Anqi Wang;  Liang Wang;  Jianhua Yin;  Li Wang;  Lijun Di;  Maggie Pui-Man Hoi;  Luchen Shan;  Xu Wu;  Yuqiang Wang
Favorite |  | TC[WOS]:3 TC[Scopus]:4 | Submit date：2020/05/21
Danshensu  Tetramethylpyrazine  Breast Cancer  Resistance  Glycolysis  P-glycoprotein  
Memantine improves cognitive function and alters hippocampal and cortical proteome in triple transgenic mouse model of Alzheimer’s disease Journal article
Experimental Neurobiology, 2019,Volume: 28,Issue: 3,Page: 390-403
Authors:  Zhou，Xinhua;  Wang，Liang;  Xiao，Wei;  Su，Zhiyang;  Zheng，Chengyou;  Zhang，Zaijun;  Wang，Yuqiang;  Xu，Benhong;  Yang，Xifei;  Hoi，Maggie Pui Man
Favorite |  | TC[WOS]:7 TC[Scopus]:6 | Submit date：2021/03/01
Alzheimer’s disease (AD)  MARK2  Memantine  Proteomic  
Tetramethylpyrazine Analogue T-006 Exerts Neuroprotective Effects against 6-Hydroxydopamine-Induced Parkinson's Disease In Vitro and In Vivo Journal article
Oxidative Medicine and Cellular Longevity, 2019,Volume: 2019
Authors:  Zhou，Hefeng;  Shao，Min;  Yang，Xuanjun;  Li，Chuwen;  Cui，Guozhen;  Gao，Cheng;  Di，Lijun;  Zhong，Hanbing;  Wang，Yuqiang;  Zhang，Zaijun;  Lee，Simon Ming Yuen
Favorite |  | TC[WOS]:5 TC[Scopus]:5 | Submit date：2021/03/01
A novel Ca2+ current blocker promotes angiogenesis and cardiac healing after experimental myocardial infarction in mice Journal article
PHARMACOLOGICAL RESEARCH, 2018,Volume: 134,Page: 109-117
Authors:  Guozhen Cui;  Qiqi Xin;  Hisa Hui Ling Tseng;  Maggie PuiMan Hoi;  Yan Wang;  Binrui Yang;  InLeng Choi;  Yuqiang Wang;  Rong Yuan;  Keji Chen;  Weihong Cong;  Simon MingYuen Lee
Favorite |  | TC[WOS]:5 TC[Scopus]:5 | Submit date：2020/01/16
Cardioprotection  Angiogenesis  Adtm  Zebrafish  Vegf  
A novel Ca2+ current blocker promotes angiogenesis and cardiac healing after experimental myocardial infarction in mice Journal article
PHARMACOLOGICAL RESEARCH, 2018,Volume: 134,Page: 109-117
Authors:  Cui, Guozhen;  Xin, Qiqi;  Tseng, Hisa Hui Ling;  Hoi, Maggie PuiMan;  Wang, Yan;  Yang, Binrui;  Choi, InLeng;  Wang, Yuqiang;  Yuan, Rong;  Chen, Keji;  Cong, Weihong;  Lee, Simon MingYuen
View | Adobe PDF | Favorite |  | TC[WOS]:5 TC[Scopus]:5 | Submit date：2018/10/30
Cardioprotection  Angiogenesis  ADTM  Zebrafish  VEGF  
A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor Journal article
FRONTIERS IN PHARMACOLOGY, 2018,Volume: 9
Authors:  Hu, Shengquan;  Hu, Huihui;  Mak, Shinghung;  Cui, Guozhen;  Lee, Mingyuen;  Shan, Luchen;  Wang, Yuqiang;  Lin, Huangquan;  Zhang, Zaijun;  Han, Yifan
Favorite |  | TC[WOS]:8 TC[Scopus]:9 | Submit date：2018/10/30
Alzheimer's disease  tetramethylpyrazine derivative  NMDA receptor  neuroprotection  oxidative stress  GSK3 beta  
Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B Journal article
NEUROPHARMACOLOGY, 2017,Volume: 126,Page: 12-24
Authors:  Guo, Baojian;  Hu, Shengquan;  Zheng, Chengyou;  Wang, Hongyu;  Luo, Fangcheng;  Li, Haitao;  Cui, Wei;  Yang, Xifei;  Cui, Guozhen;  Mak, Shinghung;  Choi, Tony Chung-Lit;  Ma, Edmond Dik-Lung;  Wang, Yuqiang;  Lee, Simon Ming Yuen;  Zhang, Zaijun;  Han, Yifan
View | Adobe PDF | Favorite |  | TC[WOS]:13 TC[Scopus]:14 | Submit date：2018/10/31
Parkinson's disease  SU4312  Neuroprotection  Myocyte enhancer factor 2D  Monoamine oxidase-B  
Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B Journal article
NEUROPHARMACOLOGY, 2017,Volume: 126,Page: 12-24
Authors:  Guo, Baojian;  Hu, Shengquan;  Zheng, Chengyou;  Wang, Hongyu;  Luo, Fangcheng;  Li, Haitao;  Cui, Wei;  Yang, Xifei;  Cui, Guozhen;  Mak, Shinghung;  Choi, Tony Chung-Lit;  Ma, Edmond Dik-Lung;  Wang, Yuqiang;  Lee, Simon Ming Yuen;  Zhang, Zaijun;  Han, Yifan
Favorite |  | TC[WOS]:13 TC[Scopus]:14 | Submit date：2018/10/30
Parkinson's disease  SU4312  Neuroprotection  Myocyte enhancer factor 2D  Monoamine oxidase-B  
Characterization of the Molecular Mechanisms Underlying the Chronic Phase of Stroke in a Cynomolgus Monkey Model of Induced Cerebral Ischemia Journal article
JOURNAL OF PROTEOME RESEARCH, 2017,Volume: 16,Issue: 3,Page: 1150-1166
Authors:  Law, Henry C. H.;  Szeto, Samuel S. W.;  Quan, Quan;  Zhao, Yun;  Zhang, Zaijun;  Krakovska, Olga;  Lui, Leong Ting;  Zheng, Chengyou;  Lee, Simon M. -Y.;  Siu, K. W. Michael;  Wang, Yuqiang;  Chu, Ivan K.
Favorite |  | TC[WOS]:8 TC[Scopus]:8 | Submit date：2018/10/30
Stroke Biology  Itraq  Cynomolgus Monkey  Brain Proteome  Ischemia  Chronic Phase