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Inhibition of the CDK9–cyclin T1 protein–protein interaction as a new approach against triple-negative breast cancer Journal article
Acta Pharmaceutica Sinica B, 2022,Volume: 12,Issue: 3,Page: 1390-1405
Authors:  Cheng, Sha Sha;  Qu, Yuan Qing;  Wu, Jia;  Yang, Guan Jun;  Liu, Hao;  Wang, Wanhe;  Huang, Qi;  Chen, Feng;  Li, Guodong;  Wong, Chun Yuen;  Wong, Vincent Kam Wai;  Ma, Dik Lung;  Leung, Chung Hang
Favorite |  | TC[WOS]:1 TC[Scopus]:0 | Submit date:2022/04/06
Epigenetics  Kinase Inhibitor  Metal Complex  Metastasis  Protein–protein Interaction  Triple-negative Breast Cancer  
A rapid and label-free DNA-based interference reduction nucleic acid amplification strategy for viral RNA detection Journal article
Biosensors and Bioelectronics, 2022,Volume: 198
Authors:  Chen, Feng;  Li, Guodong;  Wu, Chun;  Wang, Wanhe;  Ma, Dik Lung;  Leung, Chung Hang
Favorite |  | TC[WOS]:1 TC[Scopus]:4 | Submit date:2022/03/04
Coronavirus Detection  G-quadruplex  Iridium(Iii) Complex  Rolling Circle Amplification  
A small molecule HIF-1α stabilizer that accelerates diabetic wound healing Journal article
Nature Communications, 2021,Volume: 12,Issue: 1
Authors:  Li, Guodong;  Ko, Chung Nga;  Li, Dan;  Yang, Chao;  Wang, Wanhe;  Yang, Guan Jun;  Di Primo, Carmelo;  Wong, Vincent Kam Wai;  Xiang, Yaozu;  Lin, Ligen;  Ma, Dik Lung;  Leung, Chung Hang
Favorite |  | TC[WOS]:10 TC[Scopus]:15 | Submit date:2021/12/09
A bioactive ligand-conjugated iridium(III) metal-based complex as a Keap1–Nrf2 protein-protein interaction inhibitor against acetaminophen-induced acute liver injury Journal article
Redox Biology, 2021,Volume: 48
Authors:  Li, Guodong;  Liu, Hao;  Feng, Ruibing;  Kang, Tian Shu;  Wang, Wanhe;  Ko, Chung Nga;  Wong, Chun Yuen;  Ye, Min;  Ma, Dik Lung;  Wan, Jian Bo;  Leung, Chung Hang
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2022/05/13
Inhibitor  Iridium(III) complex  Kelch-like ECH-Associated protein 1  Liver injury  Nuclear factor E2-related factor 2  
An optimized BRD4 inhibitor effectively eliminates NF-κB-driven triple-negative breast cancer cells Journal article
Bioorganic Chemistry, 2021,Volume: 114
Authors:  Yang, Guan Jun;  Song, Ying Qi;  Wang, Wanhe;  Han, Quan Bin;  Ma, Dik Lung;  Leung, Chung Hang
Favorite |  | TC[WOS]:3 TC[Scopus]:2 | Submit date:2021/12/08
Acetylated Rela  Brd4  Nf-κb  Protein-protein Interaction  Tnbc  
Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 protein–protein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells Journal article
Genes and Diseases, 2021
Authors:  Cheng, Shasha;  Yang, Guan Jun;  Wang, Wanhe;  Ma, Dik Lung;  Leung, Chung Hang
Favorite |  | TC[WOS]:0 TC[Scopus]:3 | Submit date:2022/05/13
Cancer stem cells  CDK9-cyclin T1  Epithelial mesenchymal transition  Protein–protein interaction (PPI)  Triple-negative breast cancer (TNBC)  
A 7-methoxybicoumarin derivative selectively inhibits BRD4 BD2 for anti-melanoma therapy Journal article
International Journal of Biological Macromolecules, 2020,Volume: 164,Page: 3204-3220
Authors:  Yang,Guan Jun;  Wang,Wanhe;  Lei,Pui Man;  Leung,Chung Hang;  Ma,Dik Lung
Favorite |  | TC[WOS]:6 TC[Scopus]:7 | Submit date:2021/03/01
Brd4  BromoDomain Domain  Cell Metastasis And Invasion  Histone Acetylation  Melanoma  Protein–protein Interaction  Virtual Screening  
Structure-guided discovery of a luminescent theranostic toolkit for living cancer cells and the imaging behavior effect Journal article
Chemical Science, 2020,Volume: 11,Issue: 42,Page: 11404-11412
Authors:  Wu,Chun;  Wu,Ke Jia;  Liu,Jin Biao;  Wang,Wanhe;  Leung,Chung Hang;  Ma,Dik Lung
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2021/03/01
A long-lived luminogenic iridium(III) complex for acetylacetone detection in environmental samples Journal article
Sensors and Actuators, B: Chemical, 2020,Volume: 321
Authors:  Wang,Wanhe;  Yung,Tsan Ling;  Cheng,Sha Sha;  Chen,Feng;  Liu,Jin Biao;  Leung,Chung Hang;  Ma,Dik Lung
Favorite |  | TC[WOS]:15 TC[Scopus]:17 | Submit date:2021/03/01
Acetylacetone  Iridium(Iii) Dimer  Luminogenic Probe  Time-resolved Emission Spectroscopy  
Peptide-Conjugated Long-Lived Theranostic Imaging for Targeting GRPr in Cancer and Immune Cells Journal article
Angewandte Chemie - International Edition, 2020,Volume: 59,Issue: 41,Page: 17897-17902
Authors:  Wang,Wanhe;  Wu,Ke Jia;  Vellaisamy,Kasipandi;  Leung,Chung Hang;  Ma,Dik Lung
Favorite |  | TC[WOS]:10 TC[Scopus]:10 | Submit date:2021/03/01
Gastrin-releasing Peptide Receptor (Grpr)  Peptide-conjugated Transition-metal Complexes  Theranostic Agents  Time-resolved Emission Spectroscopy