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Development of a NIR iridium(III) complex for self-calibrated and luminogenic detection of boron trifluoride Journal article
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2022,Volume: 282
Authors:  Lin, Chuankai;  Wang, Jing;  Yang, Kai;  Liu, Jinbiao;  Ma, Dik Lung;  Leung, Chung Hang;  Wang, Wanhe
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/08/02
Large Stokes shift  Luminogenic probe  Naked-eye  NIR  Self-calibrated  
Homocysteine-targeting compounds as a new treatment strategy for diabetic wounds via inhibition of the histone methyltransferase SET7/9 Journal article
Experimental and Molecular Medicine, 2022
Authors:  Li, Guodong;  Li, Dan;  Wu, Chun;  Li, Shengnan;  Chen, Feng;  Li, Peng;  Ko, Chung Nga;  Wang, Wanhe;  Lee, Simon Ming Yuen;  Lin, Ligen;  Ma, Dik Lung;  Leung, Chung Hang
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/08/05
Inhibition of the CDK9–cyclin T1 protein–protein interaction as a new approach against triple-negative breast cancer Journal article
Acta Pharmaceutica Sinica B, 2022,Volume: 12,Issue: 3,Page: 1390-1405
Authors:  Cheng, Sha Sha;  Qu, Yuan Qing;  Wu, Jia;  Yang, Guan Jun;  Liu, Hao;  Wang, Wanhe;  Huang, Qi;  Chen, Feng;  Li, Guodong;  Wong, Chun Yuen;  Wong, Vincent Kam Wai;  Ma, Dik Lung;  Leung, Chung Hang
Favorite |  | TC[WOS]:4 TC[Scopus]:2 | Submit date:2022/04/06
Epigenetics  Kinase Inhibitor  Metal Complex  Metastasis  Protein–protein Interaction  Triple-negative Breast Cancer  
A rapid and label-free DNA-based interference reduction nucleic acid amplification strategy for viral RNA detection Journal article
Biosensors and Bioelectronics, 2022,Volume: 198
Authors:  Chen, Feng;  Li, Guodong;  Wu, Chun;  Wang, Wanhe;  Ma, Dik Lung;  Leung, Chung Hang
Favorite |  | TC[WOS]:3 TC[Scopus]:5 | Submit date:2022/03/04
Coronavirus Detection  G-quadruplex  Iridium(Iii) Complex  Rolling Circle Amplification  
A bioactive ligand-conjugated iridium(III) metal-based complex as a Keap1–Nrf2 protein-protein interaction inhibitor against acetaminophen-induced acute liver injury Journal article
Redox Biology, 2021,Volume: 48
Authors:  Li, Guodong;  Liu, Hao;  Feng, Ruibing;  Kang, Tian Shu;  Wang, Wanhe;  Ko, Chung Nga;  Wong, Chun Yuen;  Ye, Min;  Ma, Dik Lung;  Wan, Jian Bo;  Leung, Chung Hang
Favorite |  | TC[WOS]:9 TC[Scopus]:9 | Submit date:2022/05/13
Inhibitor  Iridium(III) complex  Kelch-like ECH-Associated protein 1  Liver injury  Nuclear factor E2-related factor 2  
A small molecule HIF-1α stabilizer that accelerates diabetic wound healing Journal article
Nature Communications, 2021,Volume: 12,Issue: 1
Authors:  Li, Guodong;  Ko, Chung Nga;  Li, Dan;  Yang, Chao;  Wang, Wanhe;  Yang, Guan Jun;  Di Primo, Carmelo;  Wong, Vincent Kam Wai;  Xiang, Yaozu;  Lin, Ligen;  Ma, Dik Lung;  Leung, Chung Hang
Favorite |  | TC[WOS]:22 TC[Scopus]:26 | Submit date:2021/12/09
An optimized BRD4 inhibitor effectively eliminates NF-κB-driven triple-negative breast cancer cells Journal article
Bioorganic Chemistry, 2021,Volume: 114
Authors:  Yang, Guan Jun;  Song, Ying Qi;  Wang, Wanhe;  Han, Quan Bin;  Ma, Dik Lung;  Leung, Chung Hang
Favorite |  | TC[WOS]:4 TC[Scopus]:3 | Submit date:2021/12/08
Acetylated Rela  Brd4  Nf-κb  Protein-protein Interaction  Tnbc  
Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 protein–protein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells Journal article
Genes and Diseases, 2021
Authors:  Cheng, Shasha;  Yang, Guan Jun;  Wang, Wanhe;  Ma, Dik Lung;  Leung, Chung Hang
Favorite |  | TC[WOS]:0 TC[Scopus]:2 | Submit date:2022/05/13
Cancer Stem Cells  Cdk9-cyclin T1  Epithelial Mesenchymal Transition  Protein–protein Interaction (Ppi)  Triple-negative Breast Cancer (Tnbc)  
A 7-methoxybicoumarin derivative selectively inhibits BRD4 BD2 for anti-melanoma therapy Journal article
International Journal of Biological Macromolecules, 2020,Volume: 164,Page: 3204-3220
Authors:  Yang,Guan Jun;  Wang,Wanhe;  Lei,Pui Man;  Leung,Chung Hang;  Ma,Dik Lung
Favorite |  | TC[WOS]:7 TC[Scopus]:9 | Submit date:2021/03/01
Brd4  BromoDomain Domain  Cell Metastasis And Invasion  Histone Acetylation  Melanoma  Protein–protein Interaction  Virtual Screening  
Structure-guided discovery of a luminescent theranostic toolkit for living cancer cells and the imaging behavior effect Journal article
Chemical Science, 2020,Volume: 11,Issue: 42,Page: 11404-11412
Authors:  Wu,Chun;  Wu,Ke Jia;  Liu,Jin Biao;  Wang,Wanhe;  Leung,Chung Hang;  Ma,Dik Lung
Favorite |  | TC[WOS]:4 TC[Scopus]:5 | Submit date:2021/03/01