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Carbon Catabolite Repression Governs Diverse Physiological Processes and Development in Aspergillus nidulans Journal article
mBio, 2022,Volume: 13,Issue: 1
Authors:  Chen, Yingying;  Dong, Liguo;  Alam, Md Ashiqul;  Pardeshi, Lakhansing;  Miao, Zhengqiang;  Wang, Fang;  Tan, Kaeling;  Hynes, Michael J.;  Kelly, Joan M.;  Wong, Koon Ho
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/05/17
Carbon catabolite repression  Carbon metabolism  Fungal physiology  Gene regulation  Transcription factor  
Chromatin profiling reveals heterogeneity in clinical isolates of the human pathogen Aspergillus fumigatus Journal article
PLoS Genetics, 2022,Volume: 18,Issue: 1
Authors:  Colabardini, Ana Cristina;  Wang, Fang;  Miao, Zhengqiang;  Pardeshi, Lakhansing;  Valero, Clara;  de Castro, Patrícia Alves;  Akiyama, Daniel Yuri;  Tan, Kaeling;  Nora, Luisa Czamanski;  Silva-Rocha, Rafael;  Marcet-Houben, Marina;  Gabaldón, Toni;  Fill, Taicia;  Wong, Koon Ho;  Goldman, Gustavo H.
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Heterogeneity in the transcriptional response of the human pathogen Aspergillus fumigatus to the antifungal agent caspofungin Journal article
Genetics, 2022,Volume: 220,Issue: 1
Authors:  Colabardini, Ana Cristina;  Wang, Fang;  Dong, Zhiqiang;  Pardeshi, Lakhansing;  Rocha, Marina Campos;  Costa, Jonas Henrique;  Dos Reis, Thaila Fernanda;  Brown, Alec;  Jaber, Qais Z.;  Fridman, Micha;  Fill, Taicia;  Rokas, Antonis;  Malavazi, Iran;  Wong, Koon Ho;  Goldman, Gustavo Henrique
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A. fumigatus  caspofungin  CrzA  transcriptome  
A Combinatorial CRISPR–Cas9 Screen Identifies Ifenprodil as an Adjunct to Sorafenib for Liver Cancer Treatment Journal article
Cancer Research, 2021,Volume: 81,Issue: 24,Page: 6219-6232
Authors:  Xu, Feng;  Tong, Man;  Tong, Cindy S.W.;  Chan, Becky K.C.;  Chu, Hoi Yee;  Wong, Tin Lok;  Fong, John H.C.;  Cheung, Maggie S.H.;  Mak, Kylie Hin Man;  Pardeshi, Lakhansing;  Huang, Yuanhua;  Wong, Koon Ho;  Choi, Gigi C.G.;  Ma, Stephanie;  Wong, Alan S.L.
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Co-option of an extracellular protease for transcriptional control of nutrient degradation in the fungus Aspergillus nidulans Journal article
Communications Biology, 2021,Volume: 4,Issue: 1
Authors:  Li, Ang;  Parsania, Chirag;  Tan, Kaeling;  Todd, Richard B.;  Wong, Koon Ho
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Transcription in fungal conidia before dormancy produces phenotypically variable conidia that maximize survival in different environments Journal article
Nature Microbiology, 2021,Volume: 6,Issue: 8,Page: 1066-1081
Authors:  Wang, Fang;  Sethiya, Pooja;  Hu, Xiaohui;  Guo, Shuhui;  Chen, Yingying;  Li, Ang;  Tan, Kaeling;  Wong, Koon Ho
Favorite |  | TC[WOS]:5 TC[Scopus]:9 | Submit date:2021/12/08
RUVBL1/2 Complex Regulates Pro-Inflammatory Responses in Macrophages via Regulating Histone H3K4 Trimethylation Journal article
Frontiers in Immunology, 2021,Volume: 12
Authors:  Zhang, Rui;  Cheung, Chris Y.;  Seo, Sang Uk;  Liu, Hang;  Pardeshi, Lakhansing;  Wong, Koon Ho;  Chow, Larry M.C.;  Chau, Mary P.;  Wang, Yixiang;  Lee, Ah Ra;  Kwon, Woon Yong;  Chen, Sheng;  Chan, Bill Kwan wai;  Wong, Kenneth;  Choy, Richard K.W.;  Ko, Ben C.B.
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Epigenetic Modulation  H3k4 Trimethylation  Macrophages  Pro-inflammatory  Ruvbl1/2  
Dissecting the heterogeneity and tumorigenesis of BRCA1 deficient mammary tumors via single cell RNA sequencing Journal article
Theranostics, 2021,Volume: 11,Issue: 20,Page: 9967-9987
Authors:  Sun, Heng;  Zeng, Jianming;  Miao, Zhengqiang;  Lei, Kuan Cheok;  Huang, Chen;  Hu, Lingling;  Su, Sek Man;  Chan, Un In;  Miao, Kai;  Zhang, Xu;  Zhang, Aiping;  Guo, Sen;  Chen, Si;  Meng, Ya;  Deng, Min;  Hao, Wenhui;  Lei, Haipeng;  Lin, Ying;  Yang, Zhonglin;  Tang, Dongjiang;  Wong, Koon Ho;  Zhang, Xiaohua Douglas;  Xu, Xiaoling;  Deng, Chu Xia
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/11/30
Brca1/BRCA1  Mammary tumor  Mrc2  Single cell RNA-seq  Tumor heterogeneity  
Cisplatin prevents breast cancer metastasis through blocking early EMT and retards cancer growth together with paclitaxel Journal article
Theranostics, 2021,Volume: 11,Issue: 5,Page: 2442-2459
Authors:  Wang,Haitao;  Guo,Sen;  Kim,Seung Jin;  Shao,Fangyuan;  Kei Ho,Joshua Wing;  Wong,Kuan Un;  Miao,Zhengqiang;  Hao,Dapeng;  Zhao,Ming;  Xu,Jun;  Zeng,Jianming;  Wong,Koon Ho;  Di,Lijun;  Wong,Ada Hang Heng;  Xu,Xiaoling;  Deng,Chu Xia
Favorite |  | TC[WOS]:8 TC[Scopus]:7 | Submit date:2021/03/02
Cisplatin  Metastasis  Neoadjuvant Therapy  Paclitaxel  Tgfβ  
Screening of chemical libraries for new antifungal drugs against aspergillus fumigatus reveals sphingolipids are involved in the mechanism of action of miltefosine Journal article
mBio, 2021,Volume: 12,Issue: 4
Authors:  Dos Reis, Thaila Fernanda;  Horta, Maria Augusta Crivelente;  Colabardini, Ana Cristina;  Fernandes, Caroline Mota;  Silva, Lilian Pereira;  Bastos, Rafael Wesley;  Fonseca, Maria Vitória de Lazari;  Wang, Fang;  Martins, Celso;  Rodrigues, Márcio L.;  Pereira, Cristina Silva;  Del Poeta, Maurizio;  Wong, Koon Ho;  Goldman, Gustavo H.
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2022/05/13
Aspergillus fumigatus  Drug repurposing  Miltefosine  Sphingolipids  Transcription factor