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Inhibition of the CDK9–cyclin T1 protein–protein interaction as a new approach against triple-negative breast cancer Journal article
Acta Pharmaceutica Sinica B, 2022,Volume: 12,Issue: 3,Page: 1390-1405
Authors:  Cheng, Sha Sha;  Qu, Yuan Qing;  Wu, Jia;  Yang, Guan Jun;  Liu, Hao;  Wang, Wanhe;  Huang, Qi;  Chen, Feng;  Li, Guodong;  Wong, Chun Yuen;  Wong, Vincent Kam Wai;  Ma, Dik Lung;  Leung, Chung Hang
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/04/06
Epigenetics  Kinase Inhibitor  Metal Complex  Metastasis  Protein–protein Interaction  Triple-negative Breast Cancer  
A review on the emerging roles of pyruvate kinase M2 in anti-leukemia therapy Journal article
International Journal of Biological Macromolecules, 2021,Volume: 193,Page: 1499-1506
Authors:  Yang, Guan Jun;  Wu, Jia;  Leung, Chung Hang;  Ma, Dik Lung;  Chen, Jiong
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2022/01/14
Leukemia  Modulators  Pyruvate Kinase M2  
Pharmacological inhibition of KDM5A for cancer treatment Journal article
European Journal of Medicinal Chemistry, 2021,Volume: 226
Authors:  Yang, Guan Jun;  Wu, Jia;  Miao, Liang;  Zhu, Ming Hui;  Zhou, Qian Jin;  Lu, Xin Jiang;  Lu, Jian Fei;  Leung, Chung Hang;  Ma, Dik Lung;  Chen, Jiong
Favorite |  | TC[WOS]:1 TC[Scopus]:0 | Submit date:2021/12/08
Cancer Therapy  Drug Resistance  Histone Methylation  Lysine-specific Demethylase 5a  Screening Methods  
A small molecule HIF-1α stabilizer that accelerates diabetic wound healing Journal article
Nature Communications, 2021,Volume: 12,Issue: 1
Authors:  Li, Guodong;  Ko, Chung Nga;  Li, Dan;  Yang, Chao;  Wang, Wanhe;  Yang, Guan Jun;  Di Primo, Carmelo;  Wong, Vincent Kam Wai;  Xiang, Yaozu;  Lin, Ligen;  Ma, Dik Lung;  Leung, Chung Hang
Favorite |  | TC[WOS]:7 TC[Scopus]:13 | Submit date:2021/12/09
An optimized BRD4 inhibitor effectively eliminates NF-κB-driven triple-negative breast cancer cells Journal article
Bioorganic Chemistry, 2021,Volume: 114
Authors:  Yang, Guan Jun;  Song, Ying Qi;  Wang, Wanhe;  Han, Quan Bin;  Ma, Dik Lung;  Leung, Chung Hang
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2021/12/08
Acetylated Rela  Brd4  Nf-κb  Protein-protein Interaction  Tnbc  
The emerging role of KDM5A in human cancer Journal article
Journal of Hematology and Oncology, 2021,Volume: 14,Issue: 1
Authors:  Yang,Guan Jun;  Zhu,Ming Hui;  Lu,Xin Jiang;  Liu,Yan Jun;  Lu,Jian Fei;  Leung,Chung Hang;  Ma,Dik Lung;  Chen,Jiong
Favorite |  | TC[WOS]:7 TC[Scopus]:6 | Submit date:2021/03/01
Cancer  Drug Resistance  Histone Methylation  Jumonji c Domain  Kdm5a  Targeted Therapy  
Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 protein–protein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells Journal article
Genes and Diseases, 2021
Authors:  Cheng, Shasha;  Yang, Guan Jun;  Wang, Wanhe;  Ma, Dik Lung;  Leung, Chung Hang
Favorite |  | TC[WOS]:0 TC[Scopus]:3 | Submit date:2022/05/13
Cancer stem cells  CDK9-cyclin T1  Epithelial mesenchymal transition  Protein–protein interaction (PPI)  Triple-negative breast cancer (TNBC)  
A 7-methoxybicoumarin derivative selectively inhibits BRD4 BD2 for anti-melanoma therapy Journal article
International Journal of Biological Macromolecules, 2020,Volume: 164,Page: 3204-3220
Authors:  Yang,Guan Jun;  Wang,Wanhe;  Lei,Pui Man;  Leung,Chung Hang;  Ma,Dik Lung
Favorite |  | TC[WOS]:6 TC[Scopus]:7 | Submit date:2021/03/01
Brd4  BromoDomain Domain  Cell Metastasis And Invasion  Histone Acetylation  Melanoma  Protein–protein Interaction  Virtual Screening  
Erratum: The design and development of covalent protein-protein interaction inhibitors for cancer treatment (Journal of Hematology and Oncology (2020) 13 (26) DOI: 10.1186/s13045-020-00850-0) Other
2020-07-24
Authors:  Cheng, Sha Sha;  Yang, Guan Jun;  Wang, Wanhe;  Leung, Chung Hang;  Ma, Dik Lung
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/12/06
The design and development of covalent protein-protein interaction inhibitors for cancer treatment Journal article
Journal of Hematology and Oncology, 2020,Volume: 13,Issue: 1
Authors:  Cheng,Sha Sha;  Yang,Guan Jun;  Wang,Wanhe;  Leung,Chung Hang;  Ma,Dik Lung
Favorite |  | TC[WOS]:0 TC[Scopus]:23 | Submit date:2021/03/01
Cancer Therapy  Covalent Inhibitors  Protein-protein Interaction