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Food bioactive small molecule databases: Deep boosting for the study of food molecular behaviors Journal article
Innovative Food Science and Emerging Technologies, 2020,Volume: 66
Authors:  Yang,Zheng Fei;  Xiao,Ran;  Luo,Fei Jun;  Lin,Qin Lu;  Ouyang,Defang;  Dong,Jie;  Zeng,Wen Bin
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/03/02
Bioactive Data  Food  Food Compound  Food Database  Small Molecule  
Altered resting-state functional connectivity of the insula in individuals with clinical high-risk and patients with first-episode schizophrenia Journal article
Psychiatry Research, 2019,Volume: 282
Authors:  Li,Xian Bin;  Wang,Lu Bin;  Xiong,Yan Bing;  Bo,Qi Jing;  He,Fan;  Li,Feng;  Hou,Wen Peng;  Wen,Yu Jie;  Wang,Xue Qi;  Yang,Ning Bo;  Mao,Zhen;  Dong,Qian Hong;  Zhang,Fei Fei;  Yang,Rui;  Wang,Di;  Xiang,Yu Tao;  Zhu,Yu Yang;  Tang,Yi Lang;  Yang,Zheng;  Wang,Chuan Yue
Favorite |  | TC[WOS]:0 TC[Scopus]:1 | Submit date:2021/03/02
Clinical high-risk  Insula  Resting-state functional connectivity  Schizophrenia  
Novel Therapeutic Anti-ADAM17 Antibody A9(B8) Enhances EGFR-TKI–Mediated Anticancer Activity in NSCLC Journal article
Translational Oncology, 2019,Volume: 12,Issue: 11,Page: 1516-1524
Authors:  Yang,Zheng;  Chan,Kin Iong;  Kwok,Hang Fai;  Tam,Kin Yip
Favorite |  | TC[WOS]:4 TC[Scopus]:3 | Submit date:2021/03/04
Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships Journal article
Bioorganic and Medicinal Chemistry Letters, 2018,Volume: 28,Issue: 21,Page: 3441-3445
Authors:  Zhang,Shao Lin;  Yang,Zheng;  Hu,Xiaohui;  Tam,Kin Yip
Favorite |  | TC[WOS]:5 TC[Scopus]:6 | Submit date:2021/03/04
Antiproliferative activity  Dichloroacetophenone  Kinase inhibition  Pyruvate dehydrogenase complex  Pyruvate dehydrogenase kinase  
Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships Journal article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018,Volume: 28,Issue: 21,Page: 3441-3445
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Tam, Kin Yip
Favorite |  | TC[WOS]:5 TC[Scopus]:6 | Submit date:2018/10/30
Pyruvate dehydrogenase kinase  Pyruvate dehydrogenase complex  Antiproliferative activity  Dichloroacetophenone  Kinase inhibition  
Inhibition of pyruvate dehydrogenase kinase 1 enhances the anti-cancer effect of EGFR tyrosine kinase inhibitors in non-small cell lung cancer Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 838,Page: 41-52
Authors:  Yang, Zheng;  Zhang, Shao-Lin;  Hu, Xiaohui;  Tam, Kin Yip
Favorite |  | TC[WOS]:12 TC[Scopus]:11 | Submit date:2018/10/30
Dichloroacetophenone  Epidermal Growth Factor Receptor  Tyrosine Kinase Inhibitor  Synergism  Hypoxia  Oxidative Phosphorylation  
Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1 Journal article
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018,Volume: 123,Page: 43-55
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Chakravarty, Harapriya;  Tam, Kin Yip
Favorite |  | TC[WOS]:7 TC[Scopus]:8 | Submit date:2018/10/30
Dichloroacetophenone  Pyruvate Dehydrogenase Kinase  Pyruvate Dehydrogenase Complex  Anticancer Activity  Metabolic Reprogramming  
Combination strategies using EGFR-TKi in NSCLC therapy: Learning from the gap between pre-clinical results and clinical outcomes Journal article
International Journal of Biological Sciences, 2018,Volume: 14,Issue: 2,Page: 204-216
Authors:  Yang,Zheng;  Tam,Kin Yip
Favorite |  | TC[WOS]:38 TC[Scopus]:40 | Submit date:2021/03/04
Chemotherapy  Combination  EGFR-TKi  Immunotherapy  NSCLC  Targeted therapy  
Combination Strategies Using EGFR-TKi in NSCLC Therapy: Learning from the Gap between Pre-Clinical Results and Clinical Outcomes Journal article
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2018,Volume: 14,Issue: 2,Page: 204-216
Authors:  Yang, Zheng;  Tam, Kin Yip
Favorite |  | TC[WOS]:38 TC[Scopus]:40 | Submit date:2018/10/30
Combination  Egfr-tki  Nsclc  Chemotherapy  Targeted Therapy  Immunotherapy  
Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells Conference paper
Authors:  Zhang, Shao-Lin;  Zhang, Wen;  Yang, Zheng;  Hu, Xiaohui;  Tam, Kin Yip
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date:2018/10/30
Pyruvate dehydrogenase kinase  Pyruvate dehydrogenase complex  Anti-proliferation  Binding affinity