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Tetramethylpyrazine Analogue T-006 Promotes the Clearance of Alpha-synuclein by Enhancing Proteasome Activity in Parkinson’s Disease Models Journal article
Neurotherapeutics, 2019,Volume: 16,Issue: 4,Page: 1225-1236
Authors:  Zhou,Hefeng;  Shao,Min;  Guo,Baojian;  Li,Chuwen;  Lu,Yucong;  Yang,Xuanjun;  ShengnanLi,;  Li,Haitao;  Zhu,Qi;  Zhong,Hanbing;  Wang,Yuqiang;  Zhang,Zaijun;  Lu,Jiahong;  Lee,Simon Ming Yuen
Favorite |  | TC[WOS]:7 TC[Scopus]:7 | Submit date:2021/03/01
Degradation  LMP7  Parkinson’s disease  Proteasome activity  α-synuclein  
Memantine improves cognitive function and alters hippocampal and cortical proteome in triple transgenic mouse model of Alzheimer’s disease Journal article
Experimental Neurobiology, 2019,Volume: 28,Issue: 3,Page: 390-403
Authors:  Zhou,Xinhua;  Wang,Liang;  Xiao,Wei;  Su,Zhiyang;  Zheng,Chengyou;  Zhang,Zaijun;  Wang,Yuqiang;  Xu,Benhong;  Yang,Xifei;  Hoi,Maggie Pui Man
Favorite |  | TC[WOS]:7 TC[Scopus]:6 | Submit date:2021/03/01
Alzheimer’s disease (AD)  MARK2  Memantine  Proteomic  
Tetramethylpyrazine Analogue T-006 Exerts Neuroprotective Effects against 6-Hydroxydopamine-Induced Parkinson's Disease In Vitro and In Vivo Journal article
Oxidative Medicine and Cellular Longevity, 2019,Volume: 2019
Authors:  Zhou,Hefeng;  Shao,Min;  Yang,Xuanjun;  Li,Chuwen;  Cui,Guozhen;  Gao,Cheng;  Di,Lijun;  Zhong,Hanbing;  Wang,Yuqiang;  Zhang,Zaijun;  Lee,Simon Ming Yuen
Favorite |  | TC[WOS]:5 TC[Scopus]:5 | Submit date:2021/03/01
A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor Journal article
FRONTIERS IN PHARMACOLOGY, 2018,Volume: 9
Authors:  Hu, Shengquan;  Hu, Huihui;  Mak, Shinghung;  Cui, Guozhen;  Lee, Mingyuen;  Shan, Luchen;  Wang, Yuqiang;  Lin, Huangquan;  Zhang, Zaijun;  Han, Yifan
Favorite |  | TC[WOS]:8 TC[Scopus]:9 | Submit date:2018/10/30
Alzheimer's disease  tetramethylpyrazine derivative  NMDA receptor  neuroprotection  oxidative stress  GSK3 beta  
Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B Journal article
NEUROPHARMACOLOGY, 2017,Volume: 126,Page: 12-24
Authors:  Guo, Baojian;  Hu, Shengquan;  Zheng, Chengyou;  Wang, Hongyu;  Luo, Fangcheng;  Li, Haitao;  Cui, Wei;  Yang, Xifei;  Cui, Guozhen;  Mak, Shinghung;  Choi, Tony Chung-Lit;  Ma, Edmond Dik-Lung;  Wang, Yuqiang;  Lee, Simon Ming Yuen;  Zhang, Zaijun;  Han, Yifan
View | Adobe PDF | Favorite |  | TC[WOS]:13 TC[Scopus]:14 | Submit date:2018/10/31
Parkinson's disease  SU4312  Neuroprotection  Myocyte enhancer factor 2D  Monoamine oxidase-B  
Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B Journal article
NEUROPHARMACOLOGY, 2017,Volume: 126,Page: 12-24
Authors:  Guo, Baojian;  Hu, Shengquan;  Zheng, Chengyou;  Wang, Hongyu;  Luo, Fangcheng;  Li, Haitao;  Cui, Wei;  Yang, Xifei;  Cui, Guozhen;  Mak, Shinghung;  Choi, Tony Chung-Lit;  Ma, Edmond Dik-Lung;  Wang, Yuqiang;  Lee, Simon Ming Yuen;  Zhang, Zaijun;  Han, Yifan
Favorite |  | TC[WOS]:13 TC[Scopus]:14 | Submit date:2018/10/30
Parkinson's disease  SU4312  Neuroprotection  Myocyte enhancer factor 2D  Monoamine oxidase-B  
Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3 beta and the ERK Pathway Journal article
CELLULAR AND MOLECULAR NEUROBIOLOGY, 2017,Volume: 37,Issue: 4,Page: 655-664
Authors:  Yu, Jie;  Zheng, Jiacheng;  Lin, Jiajia;  Jin, Linlu;  Yu, Rui;  Mak, Shinghung;  Hu, Shengquan;  Sun, Hongya;  Wu, Xiang;  Zhang, Zaijun;  Lee, Mingyuen;  Tsim, Wahkeung;  Su, Wei;  Zhou, Wenhua;  Cui, Wei;  Han, Yifan;  Wang, Qinwen
Favorite |  | TC[WOS]:13 TC[Scopus]:13 | Submit date:2018/10/30
Indirubin-3-oxime  H2O2  GSK3 beta  PI3-K  ERK  
Characterization of the Molecular Mechanisms Underlying the Chronic Phase of Stroke in a Cynomolgus Monkey Model of Induced Cerebral Ischemia Journal article
JOURNAL OF PROTEOME RESEARCH, 2017,Volume: 16,Issue: 3,Page: 1150-1166
Authors:  Law, Henry C. H.;  Szeto, Samuel S. W.;  Quan, Quan;  Zhao, Yun;  Zhang, Zaijun;  Krakovska, Olga;  Lui, Leong Ting;  Zheng, Chengyou;  Lee, Simon M. -Y.;  Siu, K. W. Michael;  Wang, Yuqiang;  Chu, Ivan K.
Favorite |  | TC[WOS]:8 TC[Scopus]:8 | Submit date:2018/10/30
Stroke Biology  Itraq  Cynomolgus Monkey  Brain Proteome  Ischemia  Chronic Phase  
Potent Protection Against MPP+ -Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine Journal article
NEUROMOLECULAR MEDICINE, 2016,Volume: 18,Issue: 4,Page: 561-572
Authors:  Shengquan Hu;  Liang Wang;  Shinghung Mak;  Zaijun Zhang;  Daping Xu;  Haitao Li;  Yide Li;  Yuanjia Hu;  Simon Ming Yuen Lee;  Yuqiang Wang;  Yifan Han
Favorite |  | TC[WOS]:6 TC[Scopus]:6 | Submit date:2020/01/16
Parkinson’s Disease  Mef2d  Neuroprotection  
Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy Journal article
Scientific Reports, 2016,Volume: 6
Authors:  Zaijun Zhang;  Gaoxiao Zhang;  Yewei Sun;  Samuel S. W. Szeto;  Henry C. H. Law;  Quan Quan;  Guohui Li;  Pei Yu;  Eiketsu Sho;  Michael K. W. Siu;  Simon M. Y. Lee;  Ivan K. Chu;  Yuqiang Wang
Favorite |  | TC[WOS]:18 TC[Scopus]:22 | Submit date:2018/11/06