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Cytosolic calcium mediates RIP1/RIP3 complex-dependent necroptosis through JNK activation and mitochondrial ROS production in human colon cancer cells. Journal article
Free Radical Biology & Medicine, 2017,Page: 433-444
Authors:  Sun, W;  Wu, XX;  Gao, HW;  Yu, J;  Zhao, WW;  Lu, J.;  Wang, JH;  Du, GH;  Chen, X. P.
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necroptosis  c-Jun N-terminal kinase  calcium  
Hypaconitine inhibits TGF-β1-induced epithelial-mesenchymal transition and suppresses adhesion, migration, and invasion of lung cancer A549 cells. Journal article
Chinese Journal of Natural Medicines, 2017,Page: 427-435
Authors:  Feng, HT;  Zhao, WW ;  Lu, J.;  Wang, Y. T.;  Chen, X. P.
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EMT  Hypaconitine  TGF-β1  NF-κB  
Chemical Constituents and Biological Research on Plants in the Genus Curcuma. Journal article
Critical Reviews in Food Science and Nutrition, 2017,Page: 1451-1523
Authors:  Sun, W;  Wang, S;  Zhao, WW;  Wu, CH;  Guo, SH;  Gao, HW;  Tao, HX;  Lu, J.;  Wang, Y. T.;  Chen, X. P.
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Chemical Constituents  Bioactivity  The Genus Curcuma  
Cryptotanshinone Induces Pro-death Autophagy through JNK Signaling Mediated by Reactive Oxygen Species Generation in Lung Cancer Cells. Journal article
Anti-Cancer Agents in Medicinal Chemistry, 2016,Page: 593-600
Authors:  Hao, WH;  Zhang, XN;  Zhao, WW;  Zhu, H;  Liu, ZY;  Lu, J.;  Chen, X. P.
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Cryptotanshinone  Autophagy  JNK  ROS  
2-Methoxy-6-acetyl-7-methyljuglone (MAM), a natural naphthoquinone, induces NO-dependent apoptosis and necroptosis by H2O2-dependent JNK activation in cancer cells. Journal article
Free Radical Biology & Medicine, 2016,Page: 61-77
Authors:  Sun, W ;  Bao, JL;  Lin, W;  Gao, HW;  Zhao, WW;  Zhang, Q. W.;  Leung, C. H.;  Ma, DL;  Lu, J.;  Chen, X. P.
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Apoptosis  Cancer  MAM  NO  Necroptosis  ROS  
Cucurbitacin B induces DNA damage, G2/M phase arrest, and apoptosis mediated by reactive oxygen species (ROS) in K562 cells Journal article
Anti-Cancer Agents in Medicinal Chemistry, 2014,Page: 1146-1153
Authors:  Guo, JJ;  Zhao, WW;  Hao, WH;  Ren, GW;  Lu, J.;  Chen, XP
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Cucurbitacin  Ros  Cell Death  Dna Damage  Cancer  
Ganoderiol A-Enriched Extract Suppresses Migration and Adhesion of MDA-MB-231 Cells by Inhibiting FAK-SRCPaxillin Cascade Pathway Journal article
PLoS ONE, 2013,Page: e76620-e76620
Authors:  Wu, GS;  Song, YL;  Yin, ZQ;  Guo, JJ;  Wang, SP;  Zhao, WW;  Chen, X. P.;  Zhang, Q. W.;  Lu, J.;  Wang, Y. T.
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ganoderiol A  migration  adhesion  FAK  paxillin  MDA-MB-231