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Oxyphylla a promotes degradation of α-synuclein for neuroprotection via activation of immunoproteasome Journal article
Aging and Disease, 2020,Volume: 11,Issue: 3,Page: 559-574
Authors:  Zhou,Hefeng;  Li,Shengnan;  Li,Chuwen;  Yang,Xuanjun;  Li,Haitao;  Zhong,Hanbing;  Lu,Jia Hong;  Lee,Simon Ming Yuen
Favorite |  | TC[WOS]:1 TC[Scopus]:1 | Submit date:2021/03/01
Degradation  Neuroprotection  Parkinson's disease  Proteasome  α-synuclein  
Tetramethylpyrazine Analogue T-006 Promotes the Clearance of Alpha-synuclein by Enhancing Proteasome Activity in Parkinson’s Disease Models Journal article
Neurotherapeutics, 2019,Volume: 16,Issue: 4,Page: 1225-1236
Authors:  Zhou,Hefeng;  Shao,Min;  Guo,Baojian;  Li,Chuwen;  Lu,Yucong;  Yang,Xuanjun;  ShengnanLi,;  Li,Haitao;  Zhu,Qi;  Zhong,Hanbing;  Wang,Yuqiang;  Zhang,Zaijun;  Lu,Jiahong;  Lee,Simon Ming Yuen
Favorite |  | TC[WOS]:7 TC[Scopus]:7 | Submit date:2021/03/01
Degradation  LMP7  Parkinson’s disease  Proteasome activity  α-synuclein  
A novel agent attenuates cardiotoxicity and improves antitumor activity of doxorubicin in breast cancer cells Journal article
JOURNAL OF CELLULAR BIOCHEMISTRY, 2019,Volume: 120,Issue: 4,Page: 5913-5922
Authors:  Ying Zhang;  Hongkuan Deng;  Hefeng Zhou;  Yucong Lu;  Luchen Shan;  Simon Ming‐Yuen Lee;  Guozhen Cui
Favorite |  | TC[WOS]:7 TC[Scopus]:7 | Submit date:2020/01/16
Antitumor  Biotin-conjugated Adtm Analog (Baa)  Cardioprotection  Cardiotoxicity  Doxorubicin (Dox)  
Tetramethylpyrazine Analogue T-006 Exerts Neuroprotective Effects against 6-Hydroxydopamine-Induced Parkinson's Disease In Vitro and In Vivo Journal article
Oxidative Medicine and Cellular Longevity, 2019,Volume: 2019
Authors:  Zhou,Hefeng;  Shao,Min;  Yang,Xuanjun;  Li,Chuwen;  Cui,Guozhen;  Gao,Cheng;  Di,Lijun;  Zhong,Hanbing;  Wang,Yuqiang;  Zhang,Zaijun;  Lee,Simon Ming Yuen
Favorite |  | TC[WOS]:5 TC[Scopus]:5 | Submit date:2021/03/01
Schisantherin a attenuates neuroinflammation in activated microglia: Role of Nrf2 activation through ERK phosphorylation Journal article
Cellular Physiology and Biochemistry, 2018,Volume: 47,Issue: 5,Page: 1769-1784
Authors:  Li,Chuwen;  Chen,Tongkai;  Zhou,Hefeng;  Zhang,Chao;  Feng,Yu;  Tang,Fan;  Hoi,Maggie Pui Man;  He,Chengwei;  Zheng,Ying;  Lee,Simon Ming Yuen
Favorite |  | TC[WOS]:20 TC[Scopus]:21 | Submit date:2021/03/01
Microglia  Neuroinflammation  NF-κB  Nrf2  Schisantherin A  
BHDPC Is a Novel Neuroprotectant That Provides Anti-neuroinflammatory and Neuroprotective Effects by Inactivating NF-kappa B and Activating PKA/CREB Journal article
FRONTIERS IN PHARMACOLOGY, 2018,Volume: 9
Authors:  Li, Chuwen;  Chen, Tongkai;  Zhou, Hefeng;  Feng, Yu;  Hoi, Maggie P. M.;  Ma, Dan;  Zhao, Chao;  Zheng, Ying;  Lee, Simon M. Y.
Favorite |  | TC[WOS]:7 TC[Scopus]:8 | Submit date:2018/10/30
Bhdpc  Neuroinflammation  Microglia  Nf-kappa b  Creb  Pka  
Inhibitory Effects of Betulinic Acid on LPS-Induced Neuroinflammation Involve M2 Microglial Polarization via CaMKK beta-Dependent AMPK Activation Journal article
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2018,Volume: 11
Authors:  Li, Chuwen;  Zhang, Chao;  Zhou, Hefeng;  Feng, Yu;  Tang, Fan;  Hoi, Maggie P. M.;  He, Chengwei;  Ma, Dan;  Zhao, Chao;  Lee, Simon M. Y.
Favorite |  | TC[WOS]:28 TC[Scopus]:28 | Submit date:2018/10/30
Amp-activated Protein Kinase  Betulinic Acid  Calmodulin-dependent Protein Kinase Beta  Microglia Polarization  Neuroinflammation  
A novel compound DT-010 protects against doxorubicin-induced cardiotoxicity in zebrafish and H9c2 cells by inhibiting reactive oxygen species-mediated apoptotic and autophagic pathways Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 820,Page: 86-96
Authors:  Tang, Fan;  Zhou, Xinhua;  Wang, Liang;  Shan, Luchen;  Li, Chuwen;  Zhou, Hefeng;  Lee, Simon Ming-Yuen;  Hoi, Maggie Pui-Man
Favorite |  | TC[WOS]:23 TC[Scopus]:21 | Submit date:2018/10/30
Cardioprotection  Anti-oxidative Stress  Anti-apoptosis  Autophagy Regulation  Zebrafish Cardiotoxicity  H9c2 Cardiomyocytes  
Schisantherin A Attenuates Neuroinflammation in Activated Microglia: Role of Nrf2 Activation Through ERK Phosphorylation Journal article
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018,Volume: 47,Issue: 5,Page: 1769-1784
Authors:  Li, Chuwen;  Chen, Tongkai;  Zhou, Hefeng;  Zhang, Chao;  Feng, Yu;  Tang, Fan;  Hoi, Maggie Pui-Man;  He, Chengwei;  Zheng, Ying;  Lee, Simon Ming-Yuen
Favorite |  | TC[WOS]:20 TC[Scopus]:21 | Submit date:2018/10/30
Schisantherin a  Neuroinflammation  Microglia  Nrf2  Nf-kappa b  
Evaluation in zebrafish model of the toxicity of rhodamine B-conjugated crotamine, a peptide potentially useful for diagnostics and therapeutics Journal article
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2017,Volume: 31,Issue: 11
Authors:  Chan, Judy Yuet-Wa;  Zhou, Hefeng;  Kwan, Yiu Wa;  Chan, Shun Wan;  Radis-Baptista, Gandhi;  Lee, Simon Ming-Yuen
Favorite |  | TC[WOS]:7 TC[Scopus]:9 | Submit date:2018/10/30
Acute Toxicity  Rhodamine B-crotamine  Screening Of Pharmaceuticals  Venom-derived Peptides  Zebrafish Model